PMID: 2492599Feb 1, 1989Paper

Effects of leuprolide in the treatment of central precocious puberty

The Journal of Pediatrics
P A Lee, J G Page

Abstract

Leuprolide acetate (D-Leu6 des-Gly-NH2(10), Pro-ethylamide9), a synthetic non-apeptide analog of naturally occurring gonadotropin releasing hormone, was used to treat 62 children with central precocious puberty. Sex steroid levels (testosterone in boys and estradiol in girls) were suppressed during treatment lasting from 3.5 to 24.9 months. Basal follicle-stimulating hormone values and both luteinizing hormone and follicle-stimulating hormone peak responses to stimulation by luteinizing hormone releasing hormone were also suppressed, although basal luteinizing hormone values did not differ. Linear growth rate and the rate of bone age advancement decreased during leuprolide therapy. Side effects were minimal. The long-term safety of this treatment has not yet been established; however, leuprolide appears to be an effective long-term therapy for central precocious puberty.

References

May 1, 1981·American Journal of Diseases of Children·P A Lee

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Citations

May 1, 1993·Indian Journal of Pediatrics·M P ColacoR U Mehta
Sep 1, 1990·The Journal of Pediatrics·M KreiterL L Levitsky
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·R S SwerdloffS Bhasin
Nov 10, 2015·International Journal of Endocrinology·H Nur Peltek KendirciZehra Aycan
Nov 1, 2007·Expert Opinion on Investigational Drugs·Andrea C WilsonCraig S Atwood
Sep 1, 1994·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·C Garner
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Jean-Claude CarelJean Louis Chaussain
Dec 6, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Dogus VuralliNurgun Kandemir
May 23, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Havva Nur Peltek KendirciZehra Aycan
Feb 12, 1998·Developmental Medicine and Child Neurology·R TrollmannH G Dörr

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