Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial

Seizure : the Journal of the British Epilepsy Association
Moritz TackeZeecam Hoovey

Abstract

BECTS (benign childhood epilepsy with centrotemporal spikes) is associated with characteristic EEG findings. This study examines the influence of anti-convulsive treatment on the EEG. In a randomized controlled trial including 43 children with BECTS, EEGs were performed prior to treatment with either Sulthiame or Levetiracetam as well as three times under treatment. Using the spike-wave-index, the degree of EEG pathology was quantified. The EEG before and after initiation of treatment was analyzed. Both treatment arms were compared and the EEG of the children that were to develop recurrent seizures was compared with those that were successfully treated. Regardless of the treatment agent, the spike-wave-index was reduced significantly under treatment. There were no differences between the two treatment groups. In an additional analysis, the EEG characteristics of the children with recurrent seizures differed statistically significant from those that did not have any further seizures. Both Sulthiame and Levetiracetam influence the EEG of children with BECTS. Persistent EEG pathologies are associated with treatment failures.

Citations

Jan 29, 2019·Expert Opinion on Drug Metabolism & Toxicology·Alberto VerrottiMaria Laura Iezzi
Aug 28, 2019·The Cochrane Database of Systematic Reviews·Rebecca BresnahanAnthony G Marson
Jun 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Seda KanmazSarenur Gokben
Oct 16, 2020·Biomedical Chromatography : BMC·Katarzyna MadejWojciech Piekoszewski
Oct 16, 2020·Seizure : the Journal of the British Epilepsy Association·Wei GuChunfeng Wu

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