PMID: 9538626Apr 16, 1998Paper

Effects of levosulpiride in patients with functional dyspepsia accompanied by delayed gastric emptying

The Korean Journal of Internal Medicine
C W SongJ H Hyun

Abstract

Levosulpiride is the levo-enantiomer of sulpiride, a well-known antiemetic, antidyspeptic and antipsychotic drug. This study was undertaken to investigate the effects of levosulpiride on dyspeptic symptoms and gastric motor function in a group of patients with functional dyspepsia showing delayed gastric emptying. Forty two eligible patients were entered into a 3 week, double-blind randomized comparison of 25mg of levosulpiride or placebo t.i.d.. Symptom assessment and gastric scintigraphy following the intake of scrambled egg sandwich, were performed in each patient before and after treatment. The improvement of symptom score in levosulpiride group was higher than the placebo group (p < 0.05). We assessed global efficacy, which was excellent in 1 (6%), good 11 (65%), fair 4 (24%), nil 1 (6%) of those receiving levosulpiride, and fair 9 (60%), nil 5 (33%), poor 1 (6%) of those receiving placebo. Levosulpiride tended to be more effective than placebo in relieving the dyspeptic symptoms especially in the subgroups of dysmotility-like (p < 0.05) and nonspecific (p < 0.05) as compared to other subgroups (p = 0.16). The reduction of gastric emptying time after levosulpiride treatment was more marked than Placebo group (p < 0.05). We...Continue Reading

References

Jan 1, 1991·Schizophrenia Bulletin·J Gerlach
Apr 1, 1989·Journal of Clinical Gastroenterology·M WegenerF Leverkus
Aug 1, 1987·British Journal of Clinical Pharmacology·M E McMurdoA S McNeilly

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Citations

Oct 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Hae-Won ShinSun J Chung
Dec 3, 2005·Journal of Gastroenterology·Mariko HojoNobuhiro Sato
Apr 8, 2003·Drugs·Vincenzo StanghelliniRoberto Corinaldesi
Sep 17, 2020·Alimentary Pharmacology & Therapeutics·Alexander C FordYeong Yeh Lee

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