Effects of levothyroxine replacement on lipid profile in patients with mild subclinical hypothyroidism

Medicina clínica
Agustín Angel Merchante-AlfaroIsidoro Martínez-Moreno

Abstract

To evaluate the effects of levothyroxine (L-T4) replacement on lipoprotein profile in patients with mild subclinical hypothyroidism, defined as a serum TSH level between 5 to 10 mU/l with a normal serum free thyroxine level. We have prospectively studied 89 patients with mild subclinical hypothyroidism -10 male, 79 female; mean (standard deviation) TSH: 7.9 (1.3) mU/l-. The thyroperoxidasa antibodies were positive in 46 subjects and were treated with L-T4. The 43 patients with thyroperoxidasa antibodies negative were used as controls. In both groups fasting lipid profiles were measured at baseline and 40 weeks. There were no significant differences in the age, serum concentrations of TSH, free thyroxine and lipid profile between 2 groups at baseline. After therapy, serum TSH levels had returned within the normal range in the L-T4 group and were now significantly lower than in the control group (p < 0.001). There were no significant differences in the changes from baseline to 40 weeks between patients in the L-T4 group and the control group for any of the lipid variables measured, expressed as the mean change in the L-T4 group minus the mean change in the control group and the 95% confidence interval (CI): total cholesterol, -0....Continue Reading

Citations

Mar 26, 2015·European Journal of Endocrinology·Ömer AkyürekZeynettin Kaya

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
George S MikhailNesreen A Khalil
Arquivos brasileiros de endocrinologia e metabologia
Ricardo Mendes MartinsMário Vaisman
Hormones : International Journal of Endocrinology and Metabolism
Maria K PoulasouchidouBasil C Tarlatzis
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Issac SachmechiPaul J Kim
© 2021 Meta ULC. All rights reserved