Effects of Lifestyle Physical Activity on Vascular Function in Asymptomatic Peripheral Arterial Disease

Medicine and Science in Sports and Exercise
Steve LaslovichMitchell J Rauh

Abstract

The purpose of this study was to examine the effects of a 12-wk in-home self-monitored physical activity (PA) program targeting a combination of lifestyle PA program on changes in endothelial reactivity, arterial stiffness, sedentary behaviors, and upright and stepping activities in individuals with asymptomatic peripheral arterial disease (APAD). Participants (n = 38) with APAD (ages 52-87 yr) were randomized to attention control (AC) or a PA sedentary reduction (PASR) group using an interactive online 3-month program focusing on increasing lifestyle PA and decreasing sedentary behaviors. The ActivPal™ PA monitor was used to measure postural and stepping parameters. Endothelial reactivity (peripheral arterial tone-reactive hyperemia index [PAT-RHI]) and augmentation index (AIx) were measured using the EndoPAT™ system at baseline and 3 months. The PASR group significantly decreased daily sit/lie hours (-0.80 ± 0.87 vs 0.18 ± 0.77 P = 0.001), increased sit-to-stand transitions per day (7.1 ± 10.5 vs -1.4 ± 5.71, P < 0.001), and increased daily step counts (2814 ± 1753 vs 742 ± 1321, P < 0.001). The PASR group also increased steps per day accumulated within specific cadence bands 61-80 steps per minute (1252 ± 447 vs 177 ± 359, P...Continue Reading

References

Dec 1, 1996·Journal of the American College of Cardiology·J Niebauer, J P Cooke
Jan 16, 2002·Vascular Medicine·M H Criqui
Jan 24, 2004·Acta Physiologica Scandinavica·N M Moyna, P D Thompson
Mar 1, 2005·Journal of the American College of Cardiology·Thanjuvar BragadeeshJonathan R Lindner
Apr 20, 2006·Atherosclerosis·C L HealdUNKNOWN Ankle Brachial Index Collaboration
Mar 28, 2007·Cleveland Clinic Journal of Medicine·Mary McGrae McDermott
Nov 11, 2009·Circulation·Curt DiehmUNKNOWN German Epidemiological Trial on Ankle Brachial Index Study Group
Jul 2, 2010·Mayo Clinic Proceedings·Jeffrey W Olin, Brett A Sealove
Jan 13, 2011·European Heart Journal·Genevieve N HealyNeville Owen
Feb 22, 2011·Journal of Vascular Surgery·Ryan J MaysJudith G Regensteiner
Jun 29, 2011·Preventive Medicine·Catrine Tudor-LockeTimothy S Church
Jul 26, 2011·Cardiology Research and Practice·Eshan PatvardhanJeffrey T Kuvin
Sep 18, 2015·Medicine and Science in Sports and Exercise·Fabiana Braga Benatti, Mathias Ried-Larsen
Sep 23, 2016·Physiological Measurement·Elisabeth A H WinklerCharlotte L Edwardson

❮ Previous
Next ❯

Citations

Feb 23, 2021·Progress in Cardiovascular Diseases·Adam A Behroozian, Joshua A Beckman
Mar 4, 2021·Scandinavian Journal of Medicine & Science in Sports·Chen ZhengStephen Heung-Sang Wong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.