Effects of Line and Pillar Array Microengineered SiO2 Thin Films on the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Langmuir : the ACS Journal of Surfaces and Colloids
Angela CarvalhoF J Monteiro

Abstract

A primary goal in bone tissue engineering is the design of implants that induce controlled, guided, and rapid healing. The events that normally lead to the integration of an implant into bone and determine the performance of the device occur mainly at the tissue-implant interface. Topographical surface modification of a biomaterial might be an efficient tool for inducing stem cell osteogenic differentiation and replace the use of biochemical stimuli. The main goal of this work was to develop micropatterned bioactive silica thin films to induce the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) only through topographical stimuli. Line and pillar micropatterns were developed by a combination of sol-gel/soft lithography and characterized by scanning electron microscopy, atomic force microscopy, and contact angle measurements. hMSCs were cultured onto the microfabricated thin films and flat control for up to 21 days under basal conditions. The micropatterned groups induced levels of osteogenic differentiation and expression of osteoblast-associated markers higher than those of the flat controls. Via comparison of the micropatterns, the pillars caused a stronger response of the osteogenic diff...Continue Reading

References

Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·A F von Recum, T G van Kooten
Jan 16, 1998·Journal of Biomedical Materials Research·B D BoyanZ Schwartz
Jun 5, 1998·Biomaterials·A Curtis, C Wilkinson
Feb 1, 2003·Differentiation; Research in Biological Diversity·Nicole I zur NiedenHans J Ahr
Apr 15, 2003·Journal of Cell Science·Ana I TeixeiraPaul F Nealey
Apr 25, 2003·Biomaterials·Kenichi MatsuzakaJohn A Jansen
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
Aug 20, 2005·Journal of Biomedical Materials Research. Part a·Pimpon UttayaratRussell J Composto
Feb 7, 2006·Biomaterials·Didier FalconnetMarcus Textor
Aug 21, 2007·Biochemical and Biophysical Research Communications·Yoshikazu MikamiMinoru Takagi
Sep 25, 2007·Nature Materials·Matthew J DalbyRichard O C Oreffo
Apr 29, 2008·Journal of Clinical Pathology·H K DattaS S Varanasi
Nov 15, 2008·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Elisabeth EngelJosep Samitier
Jan 31, 2009·Proceedings of the National Academy of Sciences of the United States of America·Seunghan OhSungho Jin
Jun 23, 2009·Acta Biomaterialia·Eun Jung KimShuvo Roy
Jul 8, 2009·Biophysical Journal·Marion GhibaudoBenoît Ladoux
Mar 2, 2010·Biomaterials·Hojeong JeonCostas P Grigoropoulos
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristopher A KilianMilan Mrksich
Mar 6, 2010·Nature Protocols·Dong QinGeorge M Whitesides
Oct 20, 2010·Biomacromolecules·Jirun SunSheng Lin-Gibson
Oct 23, 2010·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·A Pelaez-VargasF J Monteiro
Apr 5, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·A Pelaez-VargasF J Monteiro
Feb 9, 2012·Acta Biomaterialia·V V Divya RaniV Nair Shantikumar
Apr 24, 2012·Biomaterials·Mehdi NikkhahAli Khademhosseini
Oct 3, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·A CarvalhoF J Monteiro
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Michele M NavaRiccardo Pietrabissa
Jan 30, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Alejandro Pelaez-VargasFernando J Monteiro
Jun 15, 2013·Stem Cells International·Niall Logan, Peter Brett
May 23, 2014·Nature Materials·William L MurphyAdam J Engler

❮ Previous
Next ❯

Citations

May 4, 2017·Beilstein Journal of Nanotechnology·Sara Fernández-CastillejoRosa Solà
Jun 30, 2016·Nanomedicine·Abhay Pandit, Dimitrios I Zeugolis
Dec 14, 2018·Journal of Physics. Condensed Matter : an Institute of Physics Journal·M KhokhlovaW Prellier
Apr 3, 2018·Journal of Dental Research·R B P MirandaP F Cesar
Sep 26, 2019·Frontiers in Bioengineering and Biotechnology·Christiane Laranjo SalgadoFernando Jorge Mendes Monteiro
Jul 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Feng-Yi CaoXian-Zheng Zhang
Jan 19, 2021·International Journal of Nanomedicine·Cong FengXingdong Zhang
Aug 22, 2017·ACS Applied Materials & Interfaces·Qihui ZhouPatrick van Rijn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.