Effects of lipopolysaccharide on gastric stasis: role of cyclooxygenase.

Digestive Diseases and Sciences
Sonlee D WestDavid W Mercer

Abstract

This study was done to examine the role of cyclooxygenase (COX) in lipopolysaccharide (LPS)-induced gastroprotection and gastric stasis. In conscious rats, LPS dose and time dependently increased gastric luminal fluid accumulation. LPS decreased blood flow (laser Doppler) and prevented gastric injury from acidified ethanol at time points before significant fluid accumulation occurred. LPS increased COX-2 but not COX-1 expression. In contrast, LPS decreased gastric mucosal prostaglandin synthesis. LPS-induced gastric luminal fluid accumulation was negated by both nonselective COX inhibition with salicylate and selective COX-2 inhibition with NS-398 but not by selective COX-1 inhibition with SC-560. Neither salicylate nor NS-398 blocked LPS-induced gastroprotection. LPS-induced gastroprotection does not depend entirely on accumulation of luminal fluid and is independent of COX-1 and COX-2. However, the ability of LPS to cause gastric stasis and increase gastric luminal fluid accumulation involves COX-2.

References

Nov 1, 1994·Canadian Journal of Physiology and Pharmacology·B L Tepperman, B D Soper
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerK Seibert
Nov 1, 1996·The Journal of Clinical Investigation·B K ReuterJ L Wallace
Oct 1, 1996·Genome Research·C A HeidP M Williams
Apr 16, 1998·Digestive Diseases and Sciences·D W MercerT A Miller
Jul 4, 1998·European Journal of Pharmacology·L Franco, D Doria
Aug 4, 1998·The American Journal of Physiology·B JovovD J Benos
Aug 26, 1998·Scandinavian Journal of Gastroenterology·P C KonturekS J Konturek
Dec 10, 1999·British Journal of Pharmacology·N MaricicB M Peskar
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sonlee D WestDavid W Mercer
May 27, 2005·The Journal of Surgical Research·James W SuliburkDavid W Mercer

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Citations

Jan 13, 2010·The Journal of Trauma·Jeremy L WardDavid W Mercer
Apr 25, 2009·Digestive Diseases and Sciences·Jeremy L WardDavid W Mercer
Oct 8, 2009·Pharmacology & Therapeutics·Matteo FornaiCorrado Blandizzi

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