Effects of liquiritigenin treatment on the learning and memory deficits induced by amyloid beta-peptide (25-35) in rats

Behavioural Brain Research
Rui Ting LiuQiu Jun Lu

Abstract

Considerable evidence has emerged supporting the neuroprotective and cognition-preserving effects of estrogen, but these benefits are complicated by the evidence that estrogen increases the risk of certain cancers. Selective estrogen receptor modulators (SERMs) that specifically target the brain while avoiding peripheral organs offer a way to allow the application of estrogen treatment to neurodegenerative diseases with fewer undesirable effects. In an attempt to find such estrogen substitutes, liquiritigenin was discovered as a relatively selective estrogen receptor beta (ERbeta) agonist. In the present study, we extend our previous findings to investigate the effects of liquiritigenin on the learning and memory deficits and related neuropathology in Abeta(25-35) hippocampal-injected rats. Our results show that liquiritigenin treatment improves the behavioral performance of the model rats and attenuates neuronal loss in the brain. More importantly, liquiritigenin treatment decreases mRNA levels and protein expression of Notch-2, an effect that could promote the generation of new neurons. These findings provide evidence for the beneficial activity of liquiritigenin in a brain-injured rat model and support the continued investig...Continue Reading

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Citations

May 9, 2012·Cellular and Molecular Neurobiology·Yan-Fang XianXiao-Ping Lai
Aug 3, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Zhihong LinJyoti Kumar Tiwari
Nov 6, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yan-Fang XianXiao-Ping Lai
Jan 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zahra MokhtariMehrdad Roghani
Jul 24, 2013·Journal of Neurochemistry·Sarah J BertrandRosemarie M Booze
Jan 1, 2014·Journal of Agricultural and Food Chemistry·Tzu-Chien KaoGow-Chin Yen

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