Effects of Liraglutide on Myocardial Function After Cardiac Surgery: A Secondary Analysis of the Randomised Controlled GLOBE Trial

Journal of Clinical Medicine
Abraham H HulstJeroen Hermanides

Abstract

Previous studies demonstrated the cardioprotective properties of glucagon-like peptide-1 receptor agonists in patients with diabetes or cardiac disease. We investigated whether preoperative subcutaneous liraglutide improves myocardial function after cardiac surgery. We performed a pre-planned secondary analysis of adult patients undergoing cardiac surgery included in the GLOBE trial. Patients were randomised to receive 0.6 mg subcutaneous liraglutide on the evening before surgery and 1.2 mg after induction of anaesthesia, or matching placebo. Perioperative echocardiographic assessments, haemodynamic parameters, doses of vasoactive inotropic support and postoperative measurements of troponin, Creatine Kinase-MB , creatinine and lactate were compared between groups. The study population consisted of the entire intention-to-treat cohort of the GLOBE trial. In this study, 129 patients received liraglutide and 132 patients placebo. Baseline characteristics were comparable between groups. Postoperatively, 170 (65%) patients underwent echocardiography. In the liraglutide group, more patients had a normal left ventricular systolic function (68%, 59 patients) compared to placebo (53%, 44 patients), difference = 15%, 95%CI = 0-30, p = 0....Continue Reading

References

Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
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Jun 27, 2016·JACC. Basic to Translational Science·Joel P GiblettStephen P Hoole
Nov 16, 2018·Critical Care : the Official Journal of the Critical Care Forum·Abraham H HulstJeroen Hermanides

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Citations

Jun 3, 2021·Journal of Clinical Medicine·Xiaoling LiBenedikt Preckel
Jul 6, 2021·International Journal of Endocrinology·Zhaoshuang ZhongShuyue Xia

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BETA
coronary artery bypass
imaging techniques

Software Mentioned

SPSS

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