PMID: 6405433Jan 1, 1983Paper

Effects of lisuride on precopulatory and copulatory behaviour of adult male rats

Psychopharmacology
Z HlinákI Krejcí

Abstract

Lisuride (12.5, 125, 250, 400, 600, 800 micrograms/kg) injected IP 40 min prior to observation of adult, but sexually inexperienced, male rats (a) caused a dose-dependent increase in motor activity, (b) suppressed rearing completely at doses of 125 micrograms/kg and above, and (c) caused a dose-dependent increase of specific sniffing of the scent traces of an estrous female, the sniffing lasting the whole duration of a 5-min test at 800 micrograms/kg. In the presence of a passively receptive (lordotic) female, the amount of time devoted to sniffing of the scent traces decreased but was still dose-dependent. The males exhibited relatively more precopulatory behaviour towards the female at 400-800 micrograms/kg. The number of males initiating copulatory behaviour was small and comparable with saline-injected controls. When exposed to sexual stimuli from a weakly soliciting (presenting posture) female the number of lisuride-treated males (250 and 400 micrograms/kg doses were used) initiating copulation was higher in comparison with the controls. At the same time the males began to copulate mostly with short latencies and without any precopulatory behaviour towards the female. The lisuride-treated males reached ejaculation after a ...Continue Reading

References

Nov 1, 1979·Psychopharmacology·E K Silbergeld, R E Hruska
Jun 1, 1976·Hormones and Behavior·C H PhoenixR M Brenner
Jun 1, 1973·Journal of Comparative and Physiological Psychology·J J Pottier, D Baran
Feb 1, 1981·Physiology & Behavior·Z Hlinák, J Madlafousek
May 30, 1980·European Journal of Pharmacology·S AhleniusL Svensson
Apr 1, 1964·Journal of Comparative and Physiological Psychology·R E WHALEN
Dec 1, 1977·Neuroscience Letters·M Da PradaH H Keller

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Citations

Jan 1, 1990·Physiology & Behavior·M SalaE Gori
Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·Z Hlinák
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·M R Melis, A Argiolas
Apr 1, 1984·Behavioural Processes·Z Hliñák, I Dvorská
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·G FrajeseD Nerozzi
Jan 1, 1990·Annals of the New York Academy of Sciences·B B GorzalkaN V Watson
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·D Bitran, E M Hull

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