PMID: 6407065Jan 1, 1983Paper

Effects of lithium carbonate on serotonin uptake in rat blood platelets

Progress in Neuro-psychopharmacology & Biological Psychiatry
R C AroraH Y Meltzer

Abstract

1. Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/1 to 0.65 meq/l. When the serum levels were increased further to 1 meq/1, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/1 or below. 3. Addition of lithium carbonate in vitro (1 meq/1) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.

References

Jan 31, 1979·Psychopharmacology·M ScottJ B Loudon
Jan 1, 1978·Journal of Neural Transmission·A Carlsson, M Lindqvist
Sep 1, 1976·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·H HoneckerH Coper
Apr 1, 1976·British Journal of Pharmacology·A H Drummond, J L Gordon
Jan 1, 1974·Psychopharmacologia·P PoitouC Bohuon
Jun 1, 1968·Journal of Psychiatric Research·M Schou
Nov 1, 1969·British Journal of Pharmacology·J M Sneddon
Nov 1, 1969·Life Sciences·D L MurphyW E Bunney
Nov 1, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·K Kuriyama, R Speken
Dec 1, 1970·Brain Research·E L Bliss, J Ailion
May 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·R C Arora, H Y Meltzer
Apr 1, 1980·British Journal of Clinical Pharmacology·G V BornK Martin
Mar 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenK Wood
Oct 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·R C Arora, H Y Meltzer

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