Effects of lithium on cAMP-dependent protein kinase in rat brain

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
S MoriJ Perez

Abstract

We have investigated the effects of lithium treatment on cAMP-dependent protein kinase in discrete brain areas of rat by using photoaffinity labeling as well as western blotting. Lithium administered for 5 weeks resulted in a significant increase of the cAMP binding to the 52 kDa cAMP-receptor in the soluble, but not in the particulate, fractions of both hippocampus and frontal cortex. Moreover, immunoblotting experiments revealed that chronic lithium treatment significantly increased the immunoreactivity against the regulatory and the catalytic subunits of the cAMP-dependent protein kinase in the soluble fraction of both brain areas. In contrast, no appreciable effect was observed in the particulate fractions. Short-term lithium treatment induced a significant increase in the immunolabeling of the catalytic subunits in the soluble fraction of both areas; whereas, the regulatory subunits and the actin were unchanged. In the particulate fractions, short-term lithium treatment did not elicit any substantial modification. Taken together, the results of the present study add to the growing evidence indicating that components of the cAMP signalling could play a crucial role in the biochemical action of lithium.

Citations

Oct 6, 2000·Biological Psychiatry·M P VawterJ E Kleinman
Aug 29, 2003·Journal of Affective Disorders·Daniela TarditoJorge Perez
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jagadeesh S RaoFrancesca Bosetti
Jan 15, 2014·Metallomics : Integrated Biometal Science·Vincent Balter, Nathalie Vigier
Jul 7, 2009·Experimental Cell Research·Young OuFrans A van der Hoorn
Sep 16, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frederic Marmol
Sep 21, 2016·Molecular Psychiatry·G PathakM P Kelly
Jun 13, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jeverson MoreiraCynthia Marie-Claire
Aug 8, 2019·Nature Reviews. Drug Discovery·George S BaillieMichy P Kelly
Dec 26, 2001·Chemical Reviews·N J Birch

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