Sep 1, 1976

Effects of lithium on inducible enzymes of rat liver

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
G W GrierW D Pfeifer

Abstract

Chronic lithium administration to female rats results in elevation of serum corticoids, lowering of serum glucose and altered induction of liver enzymes. The cortisol induction of tyrosine transaminase is increased selectively over that of tryptophan oxygenase. The glucose induction of glucokinase following a fast is increased by chronic lithium treatment but diminished by acute treatment. These results indicate that lithium may alter the glucose metabolic set-point in rats.

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Mentioned in this Paper

Metabolic Process, Cellular
Glucokinase
GCK gene
Enzymes, antithrombotic
Lithium Measurement
Tyrosine Aminotransferase
Glucose, (beta-D)-Isomer
Adrenal Cortex Hormones
Enzymes for Treatment of Wounds and Ulcers
Fasting

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