Effects of Local Administration of Boric Acid on Posterolateral Spinal Fusion with Autogenous Bone Grafting in a Rodent Model

Biological Trace Element Research
Erkam KömürcüRaif Ozden

Abstract

Spinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible positive effects if the local administration of BA on posterolateral spinal fusion. Thirty-two rats were randomly divided into four independent groups: no material was added at the fusion area for group 1; an autogenous morselized corticocancellous bone graft was used for group 2; an autogenous morselized corticocancellous bone graft with boric acid (8.7 mg/kg) for group 3; and only boric acid was placed into the fusion area for group 4. The L4-L6 spinal segments were collected at week 6, and the assessments included radiography, manual palpation, and histomorphometry. A statistically significant difference was determined between the groups with regard to the mean histopathological scores (p = 0.002), and a paired comparison was made with the Mann-Whitney U test to detect the group/groups from which the difference originated. It was determined that only the graft + BA practice increased the histopathological score signi...Continue Reading

References

Nov 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KanataniK Chihara
Aug 1, 1996·Clinical Orthopaedics and Related Research·E D ArringtonN A Davino
May 8, 1997·Biochemical and Biophysical Research Communications·M BenderdourF Belleville
Mar 1, 1997·Biological Trace Element Research·J H Wilson, P L Ruszler
Feb 22, 2000·The Journal of Bone and Joint Surgery. American Volume·P M HuddlestonR Patel
Apr 23, 2003·Critical Reviews in Food Science and Nutrition·Tara A Devirian, Stella L Volpe
May 3, 2003·The Journal of Bone and Joint Surgery. American Volume·Jeffrey C WangJay R Lieberman
Jul 2, 2003·Biological Trace Element Research·Maria T Gallardo-WilliamsRobert E Chapin
May 6, 2004·The Spine Journal : Official Journal of the North American Spine Society·Jonathan N GrauerGary E Friedlaender
Mar 4, 2008·Archives of Oral Biology·Alejandro A GorustovichMaría B Guglielmotti
May 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Wellington K HsuJay R Lieberman
Dec 25, 2009·Journal of the Royal Society, Interface·H B PanJ Chang
Jan 16, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jun ZouHuilin Yang
Jul 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jemin DedaniaSheldon S Lin
Aug 6, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sema S HakkiErdogan E Hakki
Jun 1, 2011·Biological Trace Element Research·Xiaozhou YingChuan Zhu Lu
Sep 13, 2011·Acta orthopaedica et traumatologica turcica·Bora BostanUnal Erkorkmaz
Jul 7, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sung-Hsiung ChenJih-Yang Ko
Sep 5, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sema S HakkiForrest H Nielsen
Jan 9, 2013·The Spine Journal : Official Journal of the North American Spine Society·John D KoernerMichael J Vives
Mar 26, 2013·Tissue Engineering. Part C, Methods·Diyar DelawiWouter J A Dhert
May 21, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Wei YuanJian Dong
Jun 13, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z QiuH Yang

❮ Previous
Next ❯

Citations

Oct 23, 2018·Oral and Maxillofacial Surgery·Murat UluAlper Alkan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
H G PalaA Yavasoglu
Biological Trace Element Research
Umut Hatay GölgeSibel Cevizci
Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery
Hafiz AydinMurat Topbaş
© 2022 Meta ULC. All rights reserved