PMID: 9523570Apr 2, 1998Paper

Effects of local administration of L-, N-, and P/Q-type calcium channel blockers on spontaneous dopamine release in the striatum and the substantia nigra: a microdialysis study in rat

Journal of Neurochemistry
F BergquistH Nissbrandt

Abstract

The pivotal role for voltage-sensitive calcium channels in initiating synaptic transmitter release is undisputed, but it is only partly known to what extent the different subtypes contribute in vivo. Their importance for the dendritic release of dopamine has not been investigated in vivo previously. To evaluate comprehensively the relative importance of different voltage-sensitive calcium channel subtypes for striatal dopamine release, and to further investigate the mechanism of dendritic dopamine release in the reticulate part of substantia nigra, dopamine was measured by in vivo microdialysis in the striatum or substantia nigra of awake rats. The calcium channel blockers nimodipine, omega-conotoxin-GVIA, omega-agatoxin-IVA, and neomycin were administered locally through the dialysis probes and compared with calcium-free perfusion. Results indicate that dopamine release in the striatum is mainly dependent on N- and P/Q-type channels, but the dendritic dopamine release in the substantia nigra is mediated mainly by some other calcium-dependent mechanism, for example, calcium mobilization through T-, O-, or R-type calcium channels. A portion of the dendritic release is calcium independent but can be inhibited partially by neomyci...Continue Reading

Citations

Jul 8, 2008·Journal of Neuroendocrinology·F Bergquist, M Ludwig
Jul 16, 2010·Journal of Neurochemistry·Li BaoMargaret E Rice
May 18, 2011·The Journal of Biological Chemistry·Jose Alfredo MendezLouis-Eric Trudeau
Oct 28, 2019·Frontiers in Molecular Neuroscience·Emmanouela LeandrouKostas Vekrellis
Mar 17, 2006·Journal of Neurochemistry·Gabriel D FortinLouis-Eric Trudeau
May 27, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret E Rice, Jyoti C Patel
Mar 21, 2002·Acta Physiologica Scandinavica·N C McNaughtonA D Randall
Nov 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Saak V Ovsepian, J Oliver Dolly
Aug 14, 2018·Analytical Methods : Advancing Methods and Applications·Shamal M Gunawardhana, Susan M Lunte
Mar 9, 2011·Neuron·Matthew J Kennedy, Michael D Ehlers
Sep 24, 2011·Neuroscience·M E RiceS J Cragg

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