PMID: 8444381Jan 1, 1993Paper

Effects of local anesthetics on rat macrophage phagocytosis

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
K OgataK Ohura

Abstract

We examined whether phagocytosis by macrophages (M phi s) is affected by local anesthetics (lidocaine HCl, prilocaine HCl, mepivacaine HCl, tetracaine HCl and procaine HCl). Opsonized zymosan, fetal bovine serum and one local anesthetic were added to each M phi sample. After a 30-min incubation, M phi s were washed to make Giemsa stained slides for counting. The phagocytosis rate was calculated by counting the phagocytosizing M phi s per 200 cells with an optical microscope, and rates for the samples containing local anesthetics were compared with those for the non-treated samples. Inhibition of phagocytosis was reversible, dose-dependent and pH dependent for all local anesthetics. Tetracaine HCl inhibited phagocytosis most and procaine HCl, least. These results suggest that local anesthetics at the level of clinical use inhibit leukocyte phagocytosis and therefore may interfere with the normal function of cells fundamental to host defense.

Citations

Nov 10, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Irina GrosuEmmanuel Thienpont
Aug 30, 2000·International Journal of Immunopharmacology·Y AzumaK Ohura
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Felipe V RodriguesLydia M Ferreira
Dec 2, 2008·International Journal of Surgery·Mehmet Fatih YuzbasiogluIlhami Taner Kale
Sep 2, 2000·Anesthesiology·M W Hollmann, M E Durieux
Dec 21, 2011·The Journal of Physiology·Tadashi MatsuuraAkira Asada

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