Effects of local growth factors on the secretory function of bovine corpus luteum during the oestrous cycle and pregnancy in vitro

Reproduction, Fertility, and Development
J LiebermannA Miyamoto


The impact of insulin-like growth factor-I (IGF-I) basic fibroblast growth factor (bFGF), endothelin-1 (ET-1), tumour necrosis factor-alpha (TNF-alpha), transforming growth factor-alpha (TGF-alpha) and platelet-derived growth factor (PDGF) on the release of progesterone (P4) and oxytocin (OT) from individual bovine corpora lutea at different stages of the oestrous cycle and pregnancy was evaluated with a microdialysis system (MDS) in vitro. IGF-I (1 microgram mL-1) induced significantly the acute effects on P4 release at the late luteal stage (Days 15-18) and early pregnancy (Days 60-120), whereas bFGF (100 ng mL-1) was extremely effective in stimulating P4 release particularly during the mid-luteal stage (Days 8-12). Both peptides stimulated (P < 0.05) the release of OT throughout the three luteal stages and during early and late pregnancy (Days 30-60 and Days 150-210). ET-1 (100 ng mL-1) clearly inhibited P4 release during the early (Days 5-7) and mid-luteal phase and stimulated OT release only during the mid-luteal stage (P < 0.001). TNF-alpha (100 ng mL-1) stimulated the release of P4 exclusively at the early luteal phase (P < 0.05), whereas OT secretion was increased by TNF-alpha during all stages of the oestrous cycle (P ...Continue Reading


Jun 5, 2002·Molecular and Cellular Endocrinology·Michael F SmithGeorge W Smith
Nov 3, 2009·The Journal of Reproduction and Development·Ryo Nishimura, Kiyoshi Okuda
Jun 23, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Kathryn J WoadRobert S Robinson
Oct 27, 1999·Journal of the American Academy of Dermatology·L E ParletteH Skelton
Nov 3, 2007·Reproduction in Domestic Animals = Zuchthygiene·M P GreenM G Hunter
Mar 1, 2002·Biology of Reproduction·William A RickeMichael F Smith
Sep 19, 2002·The Journal of Veterinary Medical Science·Victor Chisha ZuluYutaka Sawamukai
Jul 23, 1998·Biology of Reproduction·U SalliT D Braden
Jul 1, 2004·Reproduction in Domestic Animals = Zuchthygiene·D Schams, B Berisha
Sep 28, 2001·Journal of Dairy Science·S M MacielL J Spicer
Feb 9, 2005·The Journal of Veterinary Medical Science·Refaat DerarYoh-Ichi Miyake
Aug 2, 2008·Reproduction, Fertility, and Development·D M GuerraJ Buratini
Apr 6, 2021·International Journal of Dermatology·Nour KibbiGauri Panse

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