Effects of local nicotinic activation of the superior colliculus on saccades in monkeys

Journal of Neurophysiology
Masayuki WatanabeTadashi Isa

Abstract

To examine the role of competitive and cooperative neural interactions within the intermediate layer of superior colliculus (SC), we elevated the basal SC neuronal activity by locally injecting a cholinergic agonist nicotine and analyzed its effects on saccade performance. After microinjection, spontaneous saccades were directed toward the movement field of neurons at the injection site (affected area). For visually guided saccades, reaction times were decreased when targets were presented close to the affected area. However, when visual targets were presented remote from the affected area, reaction times were not increased regardless of the rostrocaudal level of the injection sites. The endpoints of visually guided saccades were biased toward the affected area when targets were presented close to the affected area. After this endpoint effect diminished, the trajectories of visually guided saccades remained modestly curved toward the affected area. Compared with the effects on endpoints, the effects on reaction times were more localized to the targets close to the affected area. These results are consistent with a model that saccades are triggered by the activities of neurons within a restricted region, and the endpoints and tr...Continue Reading

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Citations

May 21, 2013·Annual Review of Neuroscience·Richard J KrauzlisAlexandre Zénon
Aug 28, 2009·Journal of Neurophysiology·Tadashi Isa, William C Hall
Jun 27, 2008·Journal of Neurophysiology·Ping Liu, Michele A Basso
Jun 20, 2008·Journal of Neurophysiology·Marie E Hemelt, Asaf Keller
Sep 29, 2011·Journal of Cognitive Neuroscience·Robert A MarinoDouglas P Munoz
Sep 15, 2017·Journal of Neurophysiology·Laurent GoffartNeeraj J Gandhi
Dec 13, 2006·The European Journal of Neuroscience·Thongchai Sooksawate, Tadashi Isa
Aug 30, 2008·Journal of Neurophysiology·Thongchai SooksawateTadashi Isa
Jun 21, 2012·The European Journal of Neuroscience·Thongchai SooksawateTadashi Isa
May 28, 2014·The European Journal of Neuroscience·Ken-ichi Okada, Yasushi Kobayashi
May 29, 2015·Journal of Neurophysiology·Elizabeth A StubblefieldGidon Felsen
Jun 16, 2017·Annual Review of Vision Science·Michele A Basso, Paul J May
Jul 24, 2015·Journal of Neurophysiology·Andrew B WolfGidon Felsen
Jun 8, 2011·The European Journal of Neuroscience·Masayuki Watanabe, Douglas P Munoz
Feb 6, 2021·Journal of Cognitive Neuroscience·Chin-An Wang, Douglas P Munoz
Aug 28, 2021·Journal of Cognitive Neuroscience·Chin-An Wang, Douglas P Munoz

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