Abstract
We evaluated the effects of pre-transplant locoregional treatment on survival in living donor liver transplantation (LDLT), and the most accurate method for predicting survival after LDLT in patients who received pre-transplant locoregional treatment. From December 2003 to December 2012, 234 patients underwent LDLT for hepatocellular carcinoma (HCC) at our transplant center. We retrospectively reviewed 86 patients newly diagnosed with HCC and who received pre-transplant locoregional treatments at our hospital. Of the 33 patients with HCC initially beyond the Milan criteria, 12 experienced successful down-staging after locoregional treatments, and the 5-year recurrence-free survival was 81.8%, which was comparable to those in patients with HCC initially within the Milan criteria. A bad responder according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) [HR, 4.874 (1.059-22.442), p = 0.042], and increased AFP levels [HR 4.002 (1.540-10.397), p = 0.004] during pre-transplant locoregional treatments were independent risk factors for HCC recurrence after LDLT in multivariate analysis. Liver transplantation may be considered after successful down-staging in patients with HCC initially beyond the Milan criteria....Continue Reading
References
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y YaoJ P Roberts
Jul 11, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gerd OttoMichael Pitton
Jan 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gunda MillonigWolfgang Vogel
Mar 8, 2008·Annals of Surgical Oncology·Shuji SumieMichio Sata
Aug 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francis Y YaoJohn P Roberts
Nov 27, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RavaioliA D Pinna
Jan 15, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E VibertR Adam
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Jan 11, 2012·Oncology·Jong Young Choi
Jul 24, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ho Jung AnEun Sun Jung
Nov 20, 2012·Clinical Transplantation·Robert C GrantIan D McGilvray
Mar 15, 2013·Seminars in Liver Disease·Jorge A Marrero
Oct 1, 2013·Surgery·Toshimi KaidoShinji Uemoto
Citations
Feb 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Min Woo LeeDavid S K Lu
Apr 13, 2018·PloS One·Min Suk ChaeSang Hyun Hong
Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laura KulikKhaled Mohammed
May 2, 2020·Journal of Cancer Research and Clinical Oncology·Astrid BauschkeUtz Settmacher
Jan 28, 2020·World Journal of Gastrointestinal Surgery·Tsung-Han WuWei-Chen Lee