Effects of locus coeruleus activation and inactivation on hippocampal formation theta rhythm in anesthetized rats.

Brain Research Bulletin
Adam BroncelJ Konopacki

Abstract

Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypotheses were tested in the present study: 1/ if the decrease in HPC level of NE is correlated with the desynchronization of HPC field potential, then the inhibition of LC would be expected to abolish HPC type 2 theta rhythm; 2/ if the increase in HPC NE level is correlated with synchronization of HPC field potential, then the stimulation of LC would be expected to produce type 2 theta. The experiments were performed using an experimental model of HPC type 2 theta rhythm recorded in urethanized rats. It was demonstrated that electrical stimulation of LC produced type 2 theta rhythm whereas procaine injection into LC, in contrast, reversibly abolished type 2 theta. The possible relation of type 2 theta rhythm with some disturbances of Alzheimer disease are addressed.

References

Jan 1, 1991·Brain Research Bulletin·A J Heynen, R S Sainsbury
Nov 1, 1991·Neuroreport·I J Kirk, N McNaughton
Jan 1, 1986·Progress in Neurobiology·B H Bland
Jan 1, 1987·Current Topics in Developmental Biology·S L Foote, J H Morrison
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D S Segal, A J Mandell
Jul 15, 1964·Experientia·A Dahlström, K Fuxe
Mar 1, 1966·The Journal of Physiology·T J Biscoe, D W Straughan
Dec 1, 1984·Electroencephalography and Clinical Neurophysiology·L S Leung
Mar 16, 1981·Brain Research·I A LangmoenP Andersen
Jul 1, 1983·Physiological Reviews·S L FooteG Aston-Jones
Sep 1, 1981·Clinical Pharmacology and Therapeutics·M Fink, P Irwin
Feb 15, 1980·The Journal of Comparative Neurology·R LoyR Y Moore
Jun 1, 1995·The European Journal of Neuroscience·A VankovS J Sara
Aug 1, 1993·Progress in Neurobiology·B H Bland, L V Colom
Jan 1, 1993·Brain Research Bulletin·R S Sainsbury, L A Partlo
May 14, 1998·Neuroscience and Biobehavioral Reviews·R S Sainsbury
May 14, 1998·Neuroscience and Biobehavioral Reviews·J Konopacki
Sep 14, 1999·Brain Research Bulletin·H GołebiewskiJ Konopacki
Feb 8, 2002·Neuron·György Buzsáki
Mar 21, 2002·Biological Psychiatry·Kim L MatthewsPaul T Francis
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mihály HajósEva Hajós-Korcsok
May 2, 2003·Hippocampus·Mary-Anne WoodnorthNeil McNaughton

❮ Previous
Next ❯

Citations

Jan 15, 2021·Neuroscience Letters·Farah Wahida SuhaimiChristian P Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.