Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
N ToriuH Hara

Abstract

We examined the effects of lomerizine, a new diphenylmethylpiperazine Ca2+ channel blocker, on the normal circulation in the optic nerve head and long posterior ciliary artery, and on endothelin-1-induced hypoperfusion in the optic nerve head in anesthetized rabbits using a hydrogen gas clearance method and laser Doppler flowmetry. These effects were compared with those of nilvadipine and pranidipine. Lomerizine (0.1 and 0.3 mg/kg, i.v.) significantly increased tissue blood flow in the optic nerve head and the putative blood flow in the long posterior ciliary artery with smaller reduction of blood pressure (0.3 mg/kg, i.v.) and without change in heart rate. On the other hand, nilvadipine (0.003 and 0.01 mg/kg, i.v.) and pranidipine (0.003 and 0.01 mg/kg, iv.) each significantly increased blood flow and lowered blood pressure. Moreover, lomerizine (0.1 and 0.3 mg/kg, i.v.) and nilvadipine (0.01 mg/kg, i.v.), when administered 5 min before an endothelin-1 injection (10(-6) M, 100 microl), inhibited the hypoperfusion in the optic nerve head. These results suggest that lomerizine improves the ocular circulation with minimal cardiovascular side effects. Therefore, lomerizine may have clinical potential for the treatment of eye disea...Continue Reading

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Citations

Aug 10, 2002·Current Neurology and Neuroscience Reports·Robert F Saul
Oct 25, 2003·Progress in Retinal and Eye Research·Vital P CostaLuis Metzner Serra
Dec 3, 2013·European Journal of Pharmacology·Chihiro Mayama
Apr 13, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·L FangManeli Mozaffarieh
Nov 12, 2015·BioMed Research International·B QuillC J O'Brien
Oct 12, 2010·Progress in Retinal and Eye Research·Makoto Araie, Chihiro Mayama
Jan 24, 2007·Life Sciences·Takashi KonnoNorimichi Nakahata
Jul 26, 2002·Journal of Glaucoma·Thomas YorioGanesh Prasanna
Dec 8, 2017·Frontiers in Neuroscience·Leanne T Y CheungKin Chiu
Jan 19, 2008·European Journal of Ophthalmology·A Uemura, A Mizota
Nov 3, 2009·European Journal of Ophthalmology·Bahri AydinBerati Hasanreisoglu
Jan 1, 2014·International Scholarly Research Notices·Feyzahan EkiciErgin Dileköz
Dec 16, 2017·International Journal of Molecular Sciences·Saori DeguchiNoriaki Nagai

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