PMID: 590838Oct 1, 1977

Effects of long chain fatty acids on solute absorption: perfusion studies in the human jejunum

H V AmmonS F Phillips


Perfusion studies were performed in healthy volunteers to test the hypothesis that net fluid secretion induced by fatty acids is accompanied by parallel reduction in solute transport. Ricinoleic acid provoked a marked net secretion of fluid and concomitantly inhibited the absorption of all solutes tested; these included glucose, xylose, L-leucine, L-lysine, Folic acid, and 2-mono-olein. Oleic acid also reduced net fluid and solute transport, but was less potent in reducing solute absorption than was ricinoleic acid. When fluid secretion was induced osmotically with mannitol, glucose and xylose absorption was not affected. The mechanism for this generalised effect of fatty acids on solute absorption is uncertain, possibly nonspecific, and might be related to mucosal damage and altered mucosal permeability induced by these agents.


Aug 1, 1976·The Journal of Clinical Investigation·W S ClineW A Olsen
Oct 1, 1975·Australian and New Zealand Journal of Medicine·V BurkeA Malajczuk
Aug 1, 1975·The American Journal of Physiology·J J HajjarA B Bikhazi
Jul 29, 1974·JAMA : the Journal of the American Medical Association
Nov 1, 1973·Clinical Science and Molecular Medicine·D L WingateS F Phillips
Sep 1, 1973·Clinical Science and Molecular Medicine·R I RussellK M Cochran
Jun 1, 1974·The Journal of Clinical Investigation·E Krag, S F Phillips
Nov 2, 1972·Biochimica Et Biophysica Acta·G E Sladen, J T Harries
May 1, 1968·The Journal of Clinical Investigation·C C CarpenterR W Steenberg
Sep 1, 1969·The American Journal of Physiology·D G LevittN Lifson
Aug 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·W M Riddell, P H Jordan
Feb 7, 1966·Biochimica Et Biophysica Acta·F Alvarado
Feb 1, 1974·The Journal of Clinical Investigation·H V AmmonS F Phillips
May 1, 1960·The Journal of Clinical Investigation·A M DAWSON, K J ISSELBACHER
Nov 29, 1964·Biochimica Et Biophysica Acta·P R LARSEND F TAPLEY


Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Bugaut
Oct 24, 1998·Nutrition·J A Walker-Smith
Jan 1, 1980·Psychopharmacology·L B HansenE F Hvidberg
Oct 1, 1986·Journal of the Royal Society of Medicine·J Glynn
May 1, 1979·The American Journal of Physiology·J J HajjarR L Scheig

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