PMID: 8614312Dec 1, 1995Paper

Effects of long-distance running on serum bilirubin

Medicine and Science in Sports and Exercise
J A De PazJ Gonzalez-Gallego

Abstract

This study was undertaken to determine the effects of long-distance running on serum bilirubin fractions. Thirteen male ultramarathon runners participating in a 100-km race volunteered for the study. Venous blood samples were obtained shortly before and immediately after the race. Decreased serum haptoglobin levels (-66%) indicated the presence of hemolysis. After accounting for plasma-volume loss, significant post-race increases were found for creatine kinase (+20-fold), creatine kinase-MB (+252%), alanine aminotransferase (+42%), aspartate aminotransferase (+193%), gammaglutamyl transpeptidase (+56%), and glutamate dehydrogenase (+58%) serum activities, suggesting that running causes alterations of both muscle and liver tissues. Serum concentration of total bilirubin was significantly elevated (+106%) following the race, with changes corresponding to both unconjugated (+96%) and conjugated esters (+283%) of the pigment and significant increases in the ratio of esterified to total bilirubin. Our data show that long-distance running causes increases in the different serum bilirubin fractions which can be accounted for both hemolysis and hepatic disturbances.

Citations

Oct 29, 2008·Gastroentérologie Clinique Et Biologique·J Watelet
Jun 17, 2014·Wilderness & Environmental Medicine·Brian R KupchakJeff S Volek
Sep 30, 2003·British Journal of Sports Medicine·Y Takarada
Oct 13, 2006·European Journal of Applied Physiology·Katsuhiko SuzukiPaul B Laursen
Jan 27, 2016·Journal of the Chinese Medical Association : JCMA·Shang-Lin ChouWei-Fong Kao
Jul 12, 2005·Clinics in Sports Medicine·Kelly W Mercer, John J Densmore
Mar 21, 2018·Sports Health·Jill N TirabassiMorteza Khodaee
Apr 13, 2018·Praxis·Beat Knechtle, Pantelis Theo Nikolaidis
Nov 5, 2014·European Journal of Applied Physiology·Roy J Shephard, Nathan Johnson
Jul 15, 2011·Journal of Sports Sciences·Kamal JanakiramanJaspal Singh Sandhu
Oct 11, 2017·Medicine and Science in Sports and Exercise·Isanete AlonsoManuel Bicho

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