Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice.

Investigative Ophthalmology & Visual Science
Tadao MaedaKrzysztof Palczewski

Abstract

Long-term effects of treatment with 9-cis-retinyl acetate (9-cis-R-Ac), an artificial retinoid prodrug, were tested on changes in rod and cone visual functions in mice. The acetyl ester of the functional geometric chromophore 9-cis-retinal was delivered by oral gavage to C57BL/6 female mice. In initial experiments, 10-month-old mice were used for the single treatment with 9-cis-R-Ac or the control vehicle. In long-term experiments, 4-month-old mice were treated with 9-cis-R-Ac monthly for 6 and 10 months. Photoreceptor status was evaluated by various electroretinographic (ERG) techniques, retinoid analyses, and retinal morphology. Opsin, the predicted target of oxidized 9-cis-R-Ac, was purified and its chromophore was characterized. Age-related changes observed in vehicle-treated mice at 10 months of age, compared with those in 4-month-old mice, included a progressive decline in ERG responses, such as a decreased rate of dark adaptation and a lowered rhodopsin/opsin ratio. Administration of 9-cis-R-Ac increased the rhodopsin regeneration ratio, and improved ERG responses and dark adaptation. Compared with vehicle-treated control animals, 10- and 14-month-old mice treated monthly with 9-cis-R-Ac for 6 or 10 months exhibited impr...Continue Reading

Citations

May 16, 2012·Photochemistry and Photobiology·Albert R Wielgus, Joan E Roberts
Jun 27, 2015·Progress in Retinal and Eye Research·Viviana GuadagniEnrica Strettoi
Mar 31, 2011·Biochimica Et Biophysica Acta·Philip D KiserKrzysztof Palczewski
May 18, 2016·Biochemistry·Avery E Sears, Krzysztof Palczewski
Nov 24, 2016·Nutrients·Bhubanananda Sahu, Akiko Maeda
May 11, 2017·The Journal of Biological Chemistry·Nathan S AlexanderBeata Jastrzebska
Dec 15, 2019·International Journal of Molecular Sciences·Joseph T Ortega, Beata Jastrzebska
Aug 3, 2013·Chemical Reviews·Philip D KiserKrzysztof Palczewski
Sep 22, 2021·The Journal of Physical Chemistry. a·Michał Andrzej KochmanAdam Kubas

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