PMID: 9186844May 1, 1997Paper

Effects of long-term administration of octreotide on sodium retention and atrial natriuretic peptide in carbon tetrachloride-induced cirrhotic rats

Journal of Hepatology
S S WangP S Wang

Abstract

To realize the roles of peripheral vasodilatation and atrial natriuretic peptide in the formation of cirrhotic ascites, the effects of long-term administration of octreotide on carbon tetrachloride-induced cirrhotic rats were evaluated. Urine sodium excretion, hemodynamics, plasma atrial natriuretic peptide levels, renin activities and aldosterone concentrations were compared between cirrhotic and control rats (protocol 1); and between octreotide- (65 micrograms/kg, twice daily for 10 days, subcutaneously) and placebo-treated (5% dextrose) cirrhotic rats (protocol 2). In an in vitro experiment, right atrial tissue of cirrhotic rats was incubated with different concentrations of octreotide to evaluate the release of atrial natriuretic peptide (protocol 3). Cirrhotic rats had significantly lower urine sodium excretion and systemic vascular resistance, and significantly higher plasma atrial natriuretic peptide levels, renin activities and aldosterone concentrations than control rats. Compared with placebo-treated cirrhotic rats, octreotide caused increased urine sodium excretion (-10 +/- 4% vs. 13 +/- 8% from baseline values, p < 0.05) and systemic vascular resistance (2.6 +/- 0.1 vs. 3.3 +/- 0.3 mmHg.min.100 g.ml-1, p < 0.05); an...Continue Reading

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Citations

Oct 10, 1998·European Journal of Clinical Investigation·H C LinC Y Hong
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan G Abraldes, Jaime Bosch
Sep 9, 2004·Japanese Heart Journal·Namlk Kemal EryolAbdurrahman Oguzhan
May 24, 2006·Scandinavian Journal of Gastroenterology·Rupert W L Leong, Gary P Jeffrey
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gilles Pomier-LayrarguesAlbert Tran
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T E JonassenJ S Petersen
Jan 19, 2006·American Journal of Physiology. Renal Physiology·Thomas E N JonassenJørgen Søberg Petersen

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