Effects of long-term administration of recombinant bovine tumor necrosis factor-alpha on glucose metabolism and growth hormone secretion in steers

American Journal of Veterinary Research
S KushibikiY Yokomizo

Abstract

To investigate the effects of long-term administration of recombinant bovine tumor necrosis factor-alpha (rbTNF) on plasma glucose and growth hormone concentrations, and to determine whether treatment with rbTNF causes insulin resistance in steers. 5 steers treated with rbTNF and 5 steers treated with saline (0.9% NaCl) solution (control). In experiment 1, rbTNF (5.0 microg/kg of body weight) or saline solution (5 ml) was administered SC daily for 12 days. Blood samples were obtained before treatment, and plasma was harvested for determination of glucose, insulin, and growth hormone (GH) concentrations. In experiment 2, insulin, glucose, or growth hormone-releasing hormone (GHRH) was administered IV on days 7, 9, and 11, respectively, after initiation of rbTNF or saline treatment in experiment 1. Plasma glucose and insulin concentrations were measured before and at various times for 4 hours after insulin or glucose administration. Plasma GH concentrations were measured at various times for 3 hours after GHRH administration. In experiment 1, administration of rbTNF resulted in hyperinsulinemia without hypoglycemia and decreased plasma GH concentrations. In experiment 2, plasma glucose concentrations were higher in steers treated...Continue Reading

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Citations

Nov 5, 2003·Frontiers in Neuroendocrinology·Massimo ScacchiFrancesco Cavagnini
May 17, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaymelynn K FarneyBarry J Bradford
Mar 12, 2011·The Veterinary Clinics of North America. Equine Practice·Rosa J Barsnick, Ramiro E Toribio
Jul 29, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Shiro Kushibiki
Jan 7, 2016·Asian-Australasian Journal of Animal Sciences·Sang-Gun RohKazuo Katoh
Jan 19, 2018·Journal of Animal Science and Biotechnology·C A MartelB J Bradford
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·M S Allen
Mar 26, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J A NikolićGy Huszenicza

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