Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study)

Asian Journal of Andrology
Hiroyuki KonakaEARTH study group

Abstract

Androgen replacement therapy (ART) efficacy on late-onset hypogonadism (LOH) has been widely investigated in Western countries; however, it remains controversial whether ART can improve health and prolong active lifestyles. We prospectively assessed long-term ART effects on the physical and mental statuses of aging men with LOH in Japan. The primary endpoint was health-related quality of life assessed by questionnaires. Secondary endpoints included glycemic control, lipid parameters, blood pressure, waist circumference, body composition, muscular strength, International Prostate Symptom Scores (IPSS), International Index of Erectile Function-5 (IIEF-5) scores, and serum prostate-specific antigen levels. Of the 1637 eligible volunteers, 334 patients > 40 years with LOH were randomly assigned to either the ART (n = 169) or control groups (n = 165). Fifty-two weeks after the initial treatment, ART significantly affected the role physical subdomain of the short form-36 health survey (SF-36) scale (P = 0.0318). ART was also associated with significant decreases in waist circumstance (P = 0.002) and serum triglyceride (TG) (P = 0.013) and with significant increases in whole-body and leg muscle mass volumes (P = 0.071 and 0.0108, resp...Continue Reading

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Citations

Aug 31, 2016·The World Journal of Men's Health·Kenneth J DeLayWayne Jg Hellstrom
Oct 19, 2016·The American Journal of Medicine·G Caleb AlexanderSonal Singh
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Sep 19, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kazuyoshi ShigeharaAtsushi Mizokami
Feb 6, 2021·Journal of Clinical Medicine·Kazuyoshi ShigeharaAtsushi Mizokami
May 25, 2021·Journal of Cachexia, Sarcopenia and Muscle·Kouji IzumiAtsushi Mizokami

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Methods Mentioned

BETA
X-ray
biopsy
equilibrium dialysis
biopsies

Software Mentioned

JMP

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