Abstract
Cerebral blood flows (CBF) were measured in the parietal cortex, the thalamus and the cerebellum by the hydrogen clearance technique in anesthetized spontaneously hypertensive rats, of which hypertension was treated for 16 weeks (long-term) or 8 weeks (short-term) with antihypertensive agents of hydralazine and guanethidine. As compared to non-treated control animals, CBF in the three regions were significantly increased while the calculated cerebrovascular resistances (CVR) were decreased in hypertension-treated animals. Such CBF and CVR changes were greater in SHR with long-term than short-term therapy. Both an increase in CBF and a decrease in CVR were closely related to a fall in the blood pressure. From the present results, it was concluded that earlier and longer treatment of hypertension could lessen or even prevent the increased CVR due to the hypertensive vascular changes, and increase CBF as a result.
References
Aug 1, 1975·Circulation Research·S StrandgaardA M Harper
Dec 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·K TamakiT Omae
Apr 1, 1976·Circulation·S Strandgaard
Aug 15, 1976·Experientia·M Fujishima, T Omae
May 1, 1974·Acta Physiologica Scandinavica·Y LundgrenB Folkow
Aug 1, 1968·Neurology·J S MeyerM Toyoda
Jan 1, 1984·Gerontology·M FujishimaT Omae
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·S VorstrupS Strandgaard
Sep 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D I BarryT G Bolwig
Jan 1, 1954·The American Journal of the Medical Sciences·J KLEH, J F FAZEKAS
Jan 1, 1956·Journal of the American Geriatrics Society·J KLEH, J F FAZEKAS
Jun 1, 1962·Circulation·G G ROWEC W CRUMPTON
Jul 1, 1948·The Journal of Clinical Investigation·S S KetyH A Shenkin
Citations
Feb 1, 1994·Journal of the Neurological Sciences·K ToyodaT Yamaguchi
Jan 1, 1993·Life Sciences·E E SoltisJ L Trowbridge
Sep 1, 1997·Journal of the Neurological Sciences·S J ChoJ S Kim
Jul 10, 2003·Neuroscience·T L MooreM B Moss
Sep 21, 2001·Journal of Hypertension·C J Dickinson
Sep 1, 1995·Angiology·H NakaneM Fujishima
Mar 29, 2001·Clinical and Experimental Hypertension : CHE·M SabbatiniF Amenta