Effects of long-term cadmium exposure on urinary metabolite profiles in mice

The Journal of Toxicological Sciences
Sailendra Nath SarmaMasahiko Satoh

Abstract

Cadmium (Cd) is a common environmental pollutant with known toxic effects on the kidney. Urinary metabolomics is a promising approach to study mechanism by which Cd-induced nephrotoxicity. The aim of this study was to elucidate the mechanism of Cd toxicity and to develop specific biomarkers by identifying urinary metabolic changes after a long-term of Cd exposure and with the critical concentration of Cd in the kidney. Urine samples were collected from wild-type 129/Sv mice after 67 weeks of 300 ppm Cd exposure and analyzed by ultra performance liquid chromatography connected with quadrupole time of flight mass spectrometer (UPLC-QTOF-MS) based metabolomics approach. A total of 40 most differentiated metabolites (9 down-regulated and 31 up-regulated) between the control and Cd-exposed group were identified. The majority of the regulated metabolites are amino acids (glutamine, L-aspartic acid, phenylalanine, tryptophan, and D-proline) indicating that amino acid metabolism pathways are affected by long-term exposure of Cd. However, there are also some nucleotides (guanosine, guanosine monophosphate, cyclic AMP, uridine), amino acid derivatives (homoserine, N-acetyl-L-aspartate, N-acetylglutamine, acetyl-phenylalanine, carboxymeth...Continue Reading

References

Mar 1, 1984·Environmental Health Perspectives·L Friberg
Jul 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·W SneddenJ R Martin
Oct 7, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L M FelsH Stolte
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·N MøllerK S Nair
Sep 13, 2000·Occupational and Environmental Medicine·L JärupC G Elinder
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·A Kelly, C A Stanley
Mar 21, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lars Järup
May 30, 2006·Medical Hypotheses·Joseph F ClarkGail J Pyne-Geithman
Jan 11, 2008·Annual Review of Pharmacology and Toxicology·Rima Kaddurah-DaoukRichard M Weinshilboum
Nov 26, 2008·Amino Acids·Guoyao WuYulong Yin
Feb 25, 2009·Toxicology and Applied Pharmacology·Jie LiuMaria B Kadiiska
Mar 11, 2009·Current Protocols in Bioinformatics·Ian J Forsythe, David S Wishart
May 5, 2009·Toxicology and Applied Pharmacology·Lars Järup, Agneta Akesson
May 13, 2009·Toxicology and Applied Pharmacology·Bruce A Fowler
Jun 2, 2009·BioTechniques·Ute Roessner, Jairus Bowne
Jan 12, 2010·Environmental Research·Junenette L PetersJennifer Weuve
Jul 16, 2010·Bioinformatics·Jianguo Xia, David S Wishart
Jun 10, 2011·Ciência & saúde coletiva·Soisungwan SatarugDonald A Sens
Apr 25, 2012·Journal of Toxicology and Environmental Health. Part a·Gary L Ginsberg
Jun 7, 2012·The Journal of Pharmacology and Experimental Therapeutics·Walter C Prozialeck, Joshua R Edwards
Aug 10, 2012·World Journal of Gastroenterology : WJG·Silvia Sookoian, Carlos J Pirola
Jan 24, 2013·Translational Psychiatry·R Kaddurah-DaoukO Fiehn
Mar 5, 2013·Toxicology and Applied Pharmacology·Magnus AkerstromGerd Sallsten
Dec 26, 2013·QJM : Monthly Journal of the Association of Physicians·A M HallR J Unwin
Aug 15, 2014·Psychological Medicine·F Scinicariello, M C Buser
Oct 25, 2014·Journal of Toxicology and Environmental Health. Part a·Yu Kyung LeeHyung Sik Kim
Mar 21, 2015·PloS One·Yoshiharu YamanobeToshihiro Takizawa
Aug 13, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jianping LiJinao Duan
Oct 10, 2015·Environmental Toxicology and Chemistry·Yinghua XuXingfen Yang
Nov 13, 2015·The Journal of Toxicological Sciences·Jin-Yong LeeMasahiko Satoh
May 7, 2016·Psychoneuroendocrinology·Toni Ali-SistoSoili M Lehto
Mar 7, 2017·Nature Reviews. Nephrology·Berthold Hocher, Jerzy Adamski

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Citations

Feb 5, 2019·International Journal of Radiation Biology·Stéphane GrisonMaâmar Souidi
Apr 4, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kylie D RockHeather B Patisaul
Aug 14, 2019·Reviews on Environmental Health·Pan DengBernhard Hennig
Nov 30, 2018·International Journal of Environmental Research and Public Health·Kun ZhouYankai Xia
Jul 2, 2019·Biological & Pharmaceutical Bulletin·Maki TokumotoMasahiko Satoh
Jul 19, 2020·Environmental Health and Preventive Medicine·Jin-Yong LeeMasahiko Satoh
Dec 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin-Yong LeeMasahiko Satoh
Nov 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tianmu HeJianyong Zhang
Jul 10, 2020·Toxicology Letters·Yasuyuki FujiwaraMasahiko Satoh

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