Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients

Nutrition
Yoichi SakuraiMasahiro Ochiai

Abstract

Although the perioperative use of immune-enhancing enteral formula (IEEF) effectively reduces the rate of infectious complications, whether chronic use of IEEF is beneficial is unknown. A prospective randomized clinical trial was performed to examine the safety and effectiveness of long-term IEEF on nutritional and immunologic status in non-surgical patients receiving total enteral nutrition through the gastrostomy access route. A total of 30 patients were randomly assigned to two groups in which they received total enteral nutrition, an IEEF (n = 15) or a regular polymeric enteral formula (control group; n = 15) for 12 wk. Nutritional and immunologic variables were periodically examined. Serum concentrations of insulin-like growth factor-I increased significantly for the IEEF group throughout the study. Although serum concentrations of dihomo-gamma-linoleic acid decreased significantly in the IEEF group, serum concentrations of eicosapentaenoic acid and docosahexaenoic acid increased significantly, as did concentrations of serum arginine and ornithine. The CD4/CD8 ratio and natural killer cell activity also increased for the IEEF group, but the differences were not significant. The B-cell fraction increased and the T-cell frac...Continue Reading

References

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Citations

Feb 28, 2008·Current Opinion in Gastroenterology·Mark H DeLegge
Jan 20, 2009·World Journal of Gastroenterology : WJG·Yusuf GunerhanEmel Ekşioglu-Demiralp
Sep 19, 2007·World Journal of Surgery·Hiroya TakeuchiSumio Matsumoto
Jun 15, 2011·Journal of Hepato-biliary-pancreatic Sciences·Hirofumi ShirakawaMasaru Konishi
Jun 2, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Yimin Chen, Sarah J Peterson
Mar 7, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jennifer R Hess, Norman A Greenberg

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