Effects of long-term denervation on the rat thyroarytenoid muscle

The Laryngoscope
Satoru MiyamaruEiji Yumoto

Abstract

To determine the effects of long-term denervation on the rat thyroarytenoid (TA) muscle and neuromuscular junctions. A quantitative histologic assessment of the TA muscle after long-term denervation. Thirty Wistar rats were euthanized 10, 18, 26, 42, and 58 weeks after left recurrent laryngeal nerve resection. The areas of the entire muscle and individual muscle fibers were evaluated using hematoxylin-eosin staining, and neuromuscular junctions were detected by immunohistochemistry. Changes after denervation were evaluated by comparing the treated (T) and untreated (U) sides (T/U ratio). The ratio of the number of nerve terminals (NTs) to that of acetylcholine receptors (AChRs) (NT/AChR ratio) was also assessed. The average T/U ratio for the entire muscle area of the denervation groups ranged between 61.1% and 72.5% and did not differ significantly. Similarly, the T/U ratios for the individual muscle fiber area ranged between 45.0% and 51.9%, and the differences were not significant. The T/U ratio of AChRs at 58 weeks (35.3 +/- 20.2%) was significantly lower than that at 10 weeks (76.3 +/- 9.0%; P < .01). The NT/AChR ratios ranged between 30.3% and 35.6% and did not differ significantly among the denervation groups. The entire ...Continue Reading

References

Jun 1, 1992·The Laryngoscope·M L ShindoV Sahgal
Mar 1, 1973·Archives of Otolaryngology·D R MorledgeT C Calcaterra
Jan 10, 1998·The Annals of Otology, Rhinology, and Laryngology·J M DelGaudio, J J Sciote
Feb 5, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·K InagiC N Ford
Mar 23, 1999·The Annals of Otology, Rhinology, and Laryngology·R C PanielloJ D Dahm
Feb 1, 1965·The Laryngoscope·H H DEDO, J H OGURA
Oct 14, 2005·The Laryngoscope·Yoshihiko KumaiEiji Yumoto
Feb 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael J ShinnersLinda K McLoon
Jun 1, 2006·The Laryngoscope·Yoshihiko KumaiEiji Yumoto

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Citations

Nov 7, 2014·The International Journal of Neuroscience·Haishan JiaoXiaodong Wang
May 3, 2016·The Journal of Nutritional Biochemistry·Rie MukaiJunji Terao
Sep 12, 2012·The Laryngoscope·Kyungah LeeDiane M Bless
Feb 4, 2010·Journal of Neuroscience Research·Petrica-Adrian Panaite, Ibtissam Barakat-Walter
Dec 4, 2009·The Laryngoscope·Chen DonghuiZheng Hongliang
Nov 23, 2011·Acta Oto-laryngologica·Satoru MiyamaruEiji Yumoto
Feb 13, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tetsuji SanukiRyosei Minoda
Apr 23, 2020·Logopedics, Phoniatrics, Vocology·Abdul-Latif HamdanRoula Hourani

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