Effects of long-term exogenous testosterone administration on ovarian morphology, determined by transvaginal (3D) ultrasound in female-to-male transsexuals

Human Reproduction
Mirte R CaanenCornelis B Lambalk

Abstract

Does long-term exogenous testosterone administration result in polycystic ovarian morphology (PCOM), determined by (3D) transvaginal ultrasound (TVU) in female-to-male transsexuals (FtMs). Long-term exogenous testosterone administration in FtMs does not result in PCOM determined by (3D) TVU. The role of androgens in the pathophysiology of polycystic ovary syndrome (PCOS) is still unclear. From animal studies, intra-ovarian androgens have been suggested to disturb folliculogenesis, through a pro-atretic effect on growing follicles. It remains debatable whether exogenous androgens induce PCOM in humans. In the past histomorphologic studies indicated that androgen administration in FtMs could cause PCO-like changes. However, ultrasound morphology is an established criterion for PCOS, TVU data of ovaries after prolonged androgen exposure are lacking. Prospective, observational, case-control study, in an academic setting, performed in 2014-2015, including 56 FtMs and 80 controls. The study population consisted of adult FtMs treated with long-term testosterone, as part of their cross-sex hormone treatment, and scheduled for sex-reassignment surgery (bilateral salpingo-oophorectomy). Prior to the operation, under anaesthetics TVU meas...Continue Reading

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Citations

Oct 5, 2018·Clinical Obstetrics and Gynecology·Molly B Moravek
Sep 17, 2018·Reviews in Endocrine & Metabolic Disorders·Natnita MattawanonVin Tangpricha
Oct 22, 2019·Human Reproduction Update·Shira BaramClifford L Librach
Mar 15, 2019·Current Opinion in Obstetrics & Gynecology·Molly B Moravek
Feb 28, 2020·Endocrinology·Molly B MoravekJohn F Randolph
Oct 6, 2020·Frontiers in Endocrinology·Kristine LøsslClaus Yding Andersen
Oct 3, 2020·Gynecologic Oncology·Ashley E StenzelKristen D Starbuck
Jan 6, 2021·Reproductive Sciences·Pilar Ferré-PujolMikiya Nakatsuka
May 15, 2021·Primary Care·Melissa N MontoyaBeverly Gray
Jul 23, 2021·Clinical Obstetrics and Gynecology·Melyssa WildeVeronica I Alaniz

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