Effects of long-term gonadotrophin-releasing hormone analog treatment on growth, growth hormone (GH) secretion, GH receptors, and GH-binding protein in the rat

Pediatric Research
E F GeversI C Robinson

Abstract

Long-acting gonadotropin-releasing hormone (GnRH) analogs (GnRH-a) suppress gonadal steroid production and are used in precocious puberty, resulting in an arrest of pubertal development, a slower epiphyseal maturation, and a deceleration of growth, but an increased final height. However, the way that GnRH-a affect growth is not clear. GnRH-a treatment might not only affect gonadal steroid production but might also modulate the GH axis and thereby affect growth. We used a rat model to investigate the long-term effects of prepubertally started GnRH-a treatment (triptorelin) on growth, spontaneous GH secretion, hepatic GH receptors (GHR), and GH-binding protein (GHBP) and compared it with surgical gonadectomy. Triptorelin affected most parameters in the same direction as surgical gonadectomy but to a lesser extent. In females, growth was enhanced by triptorelin, baseline GH secretion was decreased, and hepatic GHR and GHBP were decreased. Apart from these effects on the GH axis, reduction of the direct inhibiting effect of estrogen on growth could be responsible for the triptorelin-induced growth. In males, triptorelin treatment enhanced body weight gain and slightly enhanced gain in length. GH peak amplitude was the only paramete...Continue Reading

References

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Citations

Apr 30, 2005·Journal of Palliative Medicine·M W RabowG E Hardie
Sep 2, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·G Tonini, M Lazzerini
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·J C PainsonG S Tannenbaum
Oct 26, 2011·Nature Reviews. Endocrinology·Jan M WitSusan B Nunez
Sep 2, 2004·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Jia-Min WuYi Yang
Mar 28, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M UldallR H Jensen

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