Effects of long-term high-fat/high-energy and high-protein diets on insulin and ghrelin expression in developing rats

Endocrine Research
Xiumin WangWeizhong Gu

Abstract

This study investigated the long-term effects of high-fat/high-energy and high-protein diets on insulin secretion and ghrelin expression. Dams of Sprague-Dawley rats were fed a standard, high-fat/high-energy, or high-protein diet during pregnancy and lactation, and their pups were defined as control, high-fat and high-energy, and high-protein groups, respectively. The pups were fed the same diet as their dams after weaning. Plasma glucose, ghrelin, and insulin were analyzed on the first, third, seventh, and tenth postnatal days and at the end of second, third, fourth, eighth, and twelfth weeks. Ghrelin and insulin expression in the pancreas was measured using radioimmunoassay, double-staining immunohistochemistry, and confocal microscopy. Fasting blood glucose, plasma insulin concentrations, and homeostasis model assessment-insulin resistance index increased with age. Total plasma ghrelin concentrations decreased with age. Plasma ghrelin concentrations were negatively correlated with glucose levels in all three groups. Plasma ghrelin was negatively correlated with plasma insulin only in the high-fat and high-energy group. Insulin secretion in the high-protein and high-fat and high-energy groups and pancreatic ghrelin content, p...Continue Reading

References

Oct 4, 2000·Metabolism: Clinical and Experimental·W S ZawalichK C Zawalich
Oct 24, 2000·Genome Research·P C ReifsnyderE H Leiter
Mar 29, 2001·Diabetes·S Bonner-Weir
Apr 12, 2002·Biochemical and Biophysical Research Communications·Bernard BeckAlain Stricker-Krongrad
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin, Ambrose A Dunn-Meynell
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Seiko KitamuraYasuhiro Kuroda
Dec 23, 2003·Regulatory Peptides·Guillermo GomezGeorge H Greeley
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Catherine L PradoLori Sussel
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinDavid E Cummings
Jul 17, 2004·Regulatory Peptides·M T Vallejo-CremadesI A Gómez De Segura
Jul 19, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·María Teresa Vallejo-CremadesEnrique De Miguel
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Judith N GorskiBarry E Levin
Jan 9, 2008·The Journal of Endocrinology·Bernard Beck, Sébastien Richy
Jan 29, 2008·Current Diabetes Reviews·Toshihiko YadaMasafumi Kakei
Mar 20, 2008·World Journal of Gastroenterology : WJG·Xiu-Min WangLi-Zhong Du
Apr 25, 2008·Pharmacology & Therapeutics·Katsuya DezakiToshihiko Yada
Jul 11, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lyana Barbosa ParenteCarlos Alberto Mandarim-de-Lacerda
Oct 31, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anaya MitraNeil E Rowland
Apr 13, 2010·Journal of Molecular Endocrinology·Riccarda GranataMauro Papotti

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Citations

Jan 26, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ayelén M BlancoSuraj Unniappan
Sep 18, 2013·The Journal of Nutritional Biochemistry·Frank A DucaMihai Covasa
Jan 15, 2013·The Journal of Nutritional Biochemistry·Josephine M ForbesMelinda T Coughlan
Mar 28, 2020·Animal : an International Journal of Animal Bioscience·W M SantosP A P Ribeiro

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