PMID: 9543283May 16, 1998Paper

Effects of long-term inhaled corticosteroids on skin collagen synthesis and thickness in asthmatic patients

The European Respiratory Journal
K HaapasaariA Oikarinen

Abstract

There are only a few studies on the adverse effects of inhaled corticosteroids on the skin in asthmatic patients. Therefore, we evaluated the effect of inhaled corticosteroids on de novo collagen synthesis of skin and bone, skin thickness and the total amount of skin collagen. Twenty seven consecutive new asthmatic patients, on a moderate dose of budesonide or beclomethasone dipropionate, were invited to take part in this prospective study. Radioimmunological analyses of aminoterminal propeptides of type I and III procollagens (PINP, PIIINP, respectively) in suction blister fluid (SBF) of skin and in serum and carboxyterminal propeptide of type I procollagen (PICP) and cross-linked carbox terminal telopeptide of type I collagen (ICTP) in serum were performed at entry and after 3 and 6 months of inhaled corticosteroid treatment. Ultrasound measurements of skin thickness at two sites were performed at entry, at 3 and 6 months and after 1-2 yrs of inhaled corticosteroid treatment in 20 patients, six of whom had been prescribed one or more courses of oral corticosteroids. Skin hydroxyproline of punch biopsies was determined to measure the total amount of skin collagen (males, at entry and at 6 months). Skin thickness and the total ...Continue Reading

Citations

Nov 17, 2007·Calcified Tissue International·Rajesh PatelIgnac Fogelman
Sep 30, 2003·The Journal of Allergy and Clinical Immunology·David B AllenStanley J Szefler
Apr 7, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·David E Geller
Nov 25, 2006·Thyroid : Official Journal of the American Thyroid Association·Parviz YazdanparastJan Faergemann
Aug 9, 2003·Expert Opinion on Drug Safety·Bernard Guillot
Sep 24, 2005·Experimental Dermatology·Miquel JustCarles Ferrandiz
Feb 6, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nadja Nicole ZöllerAugust Bernd
Nov 13, 2001·American Journal of Clinical Dermatology·B Guillot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.