PMID: 7334367Dec 1, 1981Paper

Effects of long-term low dietary tryptophan intake on determinants of 5-hydroxytryptamine metabolism in the brains of young rats

Journal of Neurochemistry
D V Ashley, G Curzon

Abstract

The relationship between plasma and brain tryptophan (TRP) concentrations and brain 5-hydroxytryptamine (5-HT) metabolism was studied in weanling rats fed diets containing either 0.4 g or 1.45 g TRP/100 g casein hydrolysate. Both groups gained weight comparably though food intakes were generally higher in the low-TRP group. Severe depletion of plasma total and free TRP and of brain TRP, 5-HT, and 5-hydroxyindoleacetic acid (5-HIAA) occurred within 1 day of feeding the 0.4% TRP diet. Levels became stable after 7 days. The decreased brain TRP concentration of the rats on the 0.4% TRP diet did not cause a compensatory rise of the tryptophan hydroxylase (TRP OHase) activity in vitro. In the low-TRP group, neither plasma free TRP nor total TRP correlated significantly with brain TRP and although plasma TRP/large neutral amino acid (NAA) ratios (TRP/NAA) correlated significantly (P less than 0.05) with the time course of brain TRP, this statistical relationship depended almost completely on the variation of the TRP values alone. In the higher TRP group none of these correlations were significant. A plot of mean plasma free TRP versus brain TRP gave two distinct regression lines with similar slopes and corresponding to values before a...Continue Reading

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Citations

Jan 15, 1985·Experientia·M L De Marte, H E Enesco
Jan 1, 1983·Molecular Aspects of Medicine·D A Bender
Aug 24, 2007·Psychopharmacology·Geoffrey van der PlasseMatthijs G P Feenstra
Nov 1, 1982·Journal of Neurochemistry·G S SarnaG Curzon
Aug 30, 2016·Ageing Research Reviews·Holly M Brown-Borg, Rochelle Buffenstein
Dec 6, 2003·Eating and Weight Disorders : EWD·H Cavaliere, G Medeiros-Neto

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