Effects of long-term methylphenidate treatment: a pilot follow-up clinical and SPECT study

Progress in Neuro-psychopharmacology & Biological Psychiatry
Aynur Pekcanlar AkayHatice Durak

Abstract

Although abnormalities in the regional cerebral blood flow (rCBF) responses to methylphenidate (MPH) treatment have been reported in children with attention deficit hyperactivity disorder (ADHD), there are few prospective longitudinal studies assessing the long-term effects of MPH and discontinuation effects after chronic treatment. The authors studied ten drug-naive children (2 girls, 8 boys, mean age+/-S.D.=9.60+/-1.96) diagnosed with ADHD by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnostic criteria, using (99m)Tc-HMPAO-single photon emission computed tomography (SPECT). Patients were studied at baseline (visit 1), after 2 months of MPH treatment (visit 2) and after a drug-free period of 2 months following 12 months of MPH treatment (visit 3) at doses of 1 mg/kg/day. We evaluated SPECT data visually and semi-quantitatively. Two months of chronic MPH treatment resulted in visually detectable improvement in hypoperfusion in the right frontal cortex and all areas of temporal cortex with the exception of left lateral temporal cortex. This improvement was still detectable on visual evaluations of SPECT data after 2 months of treatment discontinuation. The treatment effects that were detected visually w...Continue Reading

References

Nov 15, 1990·The New England Journal of Medicine·A J ZametkinR M Cohen
Jan 1, 1989·Archives of Neurology·H C LouJ B Nielsen
Sep 1, 1989·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Goodman, J Stevenson
Jan 1, 1995·Clinical Nuclear Medicine·K G SiegJ A Hellings
May 1, 1993·Archives of General Psychiatry·A J ZametkinR M Cohen
Jun 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J A MatochikA J Zametkin
Mar 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·S R PliszkaJ W Maas
Mar 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·B J CaseyJ L Rapoport
Jun 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·F LevyI Waldman
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J VaidyaJ D Gabrieli
Feb 24, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·J H NewcornB Vitiello
Dec 1, 2001·Journal of Neural Transmission·G SpallettaC Caltagirone
Oct 9, 2002·JAMA : the Journal of the American Medical Association·F Xavier CastellanosJudith L Rapoport
Feb 21, 2003·Annals of Nuclear Medicine·Gamze Capa KayaHatice Durak
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Claudia M SzobotLuis A P Rohde
Dec 17, 2003·Biological Psychiatry·Cindy L BrandonFrancis J White
Sep 25, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Claudia SzobotLuis Augusto Rohde
Mar 29, 2006·Journal of Child Neurology·Arie LevineMordechai Lorberboym

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Citations

Mar 25, 2011·Attention Deficit and Hyperactivity Disorders·I Paul-JordanovC Gawrilow
Jun 22, 2011·Journal of Psychiatric Research·Martin SchecklmannMarcel Romanos
Dec 24, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Felipe SchmitzAngela T S Wyse

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