PMID: 6105903Sep 29, 1980Paper

Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach

Brain Research
P D Gorin, E M Johnson

Abstract

Adult rats immunized with 2.5S mouse nerve growth factor (NGF) produced antibodies which cross-reacted with rat NGF. By the criterion of ammonium sulfate precipitation followed by Sephadex G-200 chromatography, all serum anti-NGF activity was retained in the IgG fraction. Animals which developed and maintained chronic (5-6 months) serum titers of anti-NGF demonstrated a pronounced biochemical and morphological atrophy of the superior cervical ganglion which was accompanied by a 35-40% reduction in neuronal number. Norepinephrine was reduced by approximately 90% in heart and brown fat. The extent of biochemical atrophy correlated well with serum titers of anti-NGF. No effects were observed on the short adrenergic neurons of the vas deferens, adrenal medullary chromaffin cells, central adrenergic neurons, of peripheral sensory neurons. These results strongly suggest that mature peripheral sympathetic neurons remain dependent on NGF for survival as well as for maintenance.

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Citations

Jul 29, 1982·Brain Research·J P SchwartzE M Johnson
Aug 19, 1982·Brain Research·P M Richardson, T Ebendal
May 20, 1982·Brain Research·E M JohnsonJ Pearson
Apr 1, 1994·Pharmacology & Therapeutics·D N IshiiS F Pu
Apr 1, 1994·Journal of the Autonomic Nervous System·W D SteersW C de Groat
Oct 1, 1994·Journal of the Autonomic Nervous System·J B TuttleE Nataluk
Jul 15, 1994·Brain Research. Developmental Brain Research·J P NaftelJ M Bernanke
Sep 1, 1993·Trends in Neurosciences·G R Lewin, L M Mendell
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Nov 1, 1984·Neuroscience·W G Hopkins, J R Slack
Jul 1, 1982·Brain Research Bulletin·R M KostrzewaR Brus
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Y Dimberg, T Ebendal
Dec 31, 1997·Journal of Neuroimmunology·J R Tonra, L M Mendell
Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Jun 29, 2013·Cell Death & Disease·A J KoleM Deshmukh
Sep 28, 1998·The European Journal of Neuroscience·D L BennettS B McMahon
Sep 30, 1998·The European Journal of Neuroscience·P GanjuI F James
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J DiamondB Visheau
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R E Rydel, L A Greene
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J FederoffJ A Kessler

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