Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy

Reproduction : the Official Journal of the Society for the Study of Fertility
Daniel W BaileyGreg A Johnson

Abstract

In pigs, endometrial functions are regulated primarily by progesterone and placental factors including estrogen. Progesterone levels are high throughout pregnancy to stimulate and maintain secretion of histotroph from uterine epithelia necessary for growth, implantation, placentation, and development of the conceptus (embryo and its extra-embryonic membranes). This study determined effects of long-term progesterone on development and histoarchitecture of endometrial luminal epithelium (LE), glandular epithelium (GE), and vasculature in pigs. Pigs were ovariectomized during diestrus (day 12), and then received daily injections of either corn oil or progesterone for 28 days. Prolonged progesterone treatment resulted in increased weight and length of the uterine horns, and thickness of the endometrium and myometrium. Hyperplasia and hypertrophy of GE were not evident, but LE cell height increased, suggesting elevated secretory activity. Although GE development was deficient, progesterone supported increased endometrial angiogenesis comparable to that of pregnancy. Progesterone also supported alterations to the apical and basolateral domains of LE and GE. Dolichos biflorus agglutinin lectin binding and α(v) integrin were downregula...Continue Reading

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Citations

Dec 14, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Sachiko YamakoshiKazuhiko Imakawa
Sep 10, 2013·Reproductive Biology·Anita FranczakGenowefa Kotwica
Jun 8, 2012·Anatomia, histologia, embryologia·M-C Madekurozwa
Feb 12, 2015·Journal of Animal Science and Biotechnology·Greg A JohnsonFuller W Bazer
Feb 11, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Pongpat KiatprasertSutthasinee Poonyachoti
Sep 6, 2018·Annual Review of Animal Biosciences·Thomas E SpencerFrank F Bartol
Jun 29, 2012·The Journal of Reproduction and Development·Fuller W BazerGwonhwa Song
Jan 8, 2020·Animal : an International Journal of Animal Bioscience·B B D MuroA F C de Andrade

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