Effects of long-term propranolol and octreotide on postprandial hemodynamics in cirrhosis: a randomized, controlled trial

Gastroenterology
Julio D VorobioffHugo Tanno

Abstract

Postprandial increases in portal pressure may influence esophageal variceal rupture. The effects of chronic propranolol and octreotide (100 and 200 microg subcutaneously in a single dose) on postprandial hemodynamics were evaluated. FIRST STUDY: 36 cirrhotic patients were studied at baseline and 30 and 60 minutes after a standard meal and then treated with propranolol (139 +/- 9 mg/d during 39 +/- 2 days). SECOND STUDY: After baseline measurements, patients were randomized into 3 groups: (1) placebo, (2) octreotide (100 microg), or (3) octreotide (200 microg) (n = 12 for each group). Thirty minutes postinjection a new baseline was established and measurements were repeated 30 and 60 minutes after the meal. First study: Baseline portal pressure was 18.1 +/- 1.2 mm Hg, 30 and 60 minutes after the meal it was 21.5 +/- 0.8 mm Hg and 20.5 +/- 0.8 mm Hg, respectively (both P < 0.01 vs. baseline). Cardiac index (CI) was 4.5 +/- 0.2, 4.8 +/- 0.2, and 4.9 +/- 0.2 L x min(-1) x m(-2), respectively (both P < 0.05 vs. baseline). Peripheral vascular resistance was 1012 +/- 56, 902 +/- 51 (P = NS), and 884 +/- 49 dynes x sec x cm(-5) (P< 0.05 vs. baseline), respectively. Second study: Propranolol and placebo did not blunt postprandial increa...Continue Reading

Citations

Oct 11, 2003·Alimentary Pharmacology & Therapeutics·P SchiedermaierT Sauerbruch
Jul 5, 2007·The American Journal of Gastroenterology·Julio D VorobioffHugo E Tanno
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lia BellisJuan Rodés
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gilles Pomier-LayrarguesAlbert Tran
Dec 25, 2004·European Journal of Gastroenterology & Hepatology·Annalisa BerzigottiMarco Zoli
Feb 11, 2005·Current Opinion in Gastroenterology·Guadalupe Garcia-Tsao
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·H Reynaert, A Geerts
Mar 31, 2021·The Cochrane Database of Systematic Reviews·Maria Corina Plaz TorresKurinchi Selvan Gurusamy
Apr 7, 2021·The Cochrane Database of Systematic Reviews·Davide RoccarinaKurinchi Selvan Gurusamy

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