Effects of long-term testosterone administration on gonadotropin secretion in agonadal female to male transsexuals compared with hypogonadal and normal women

The Journal of Clinical Endocrinology and Metabolism
T SpinderH van Kessel

Abstract

We investigated the effects of long term testosterone (T) administration on pulsatile gonadotropin secretion in agonadal women and the effects of estradiol (E2) on gonadotropin secretion in eugonadal women in the follicular phase of the menstrual cycle. We studied 4 groups: A) 28 eugonadal women in the early follicular phase of the menstrual cycle, B) 11 hypogonadal women, C) 13 agonadal female to male (f-t-m) transsexuals treated for at least 3 months with 120-160 mg T undecanoate (TU)/day, orally, and D) 5 agonadal f-to-m transsexuals treated for at least 6 months with 250 mg of a mixture of testosterone esters, im (im T-esters), every 2 weeks. The eugonadal women in the early follicular phase had a mean serum E2 level of 193 +/- 94 (+/- SD) pmol/L, significantly higher (P less than 0.01) than that in the hypogonadal women (60 +/- 24 pmol/L), whereas there was no difference in the mean serum T levels (1.8 +/- 0.7 vs. 2.3 +/- 1.5 nmol/L). the higher serum E2 level in the eugonadal women was associated with a significantly lower mean serum LH level (6.9 +/- 2.6 vs. 44.6 +/- 17.6 U/L; P less than 0.01) and LH pulse amplitude (2.8 +/- 1.0 vs. 12.6 +/- 4.8 U/L; P less than 0.01), whereas the mean nadir LH interval did not differ b...Continue Reading

Citations

Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·A E Taylor
Mar 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Dezhong J Liao, Robert B Dickson
Dec 18, 1998·Journal of Endocrinological Investigation·P Moghetti, R Castello
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Oct 10, 2007·Journal of Endocrinological Investigation·A BachelotF Kuttenn
Jul 20, 2007·The Journal of Sexual Medicine·Jens W JacobeitHeinrich M Schulte
Apr 11, 2001·Obstetrics and Gynecology Clinics of North America·B N KalroS L Berga
Jul 1, 1997·The Journal of Clinical Endocrinology and Metabolism·J M ElbersL J Gooren
Jan 6, 2019·Journal of Assisted Reproduction and Genetics·Marco NoventaMauro Cozzolino

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