Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats

The Journal of Endocrinology
Martina BöttnerWolfgang Wuttke

Abstract

Hormone replacement therapy (HRT) has been used for several decades to treat menopausal discomforts. However, in the light of recent studies that draw attention to the potential hazards of conventional HRT, various attempts have been undertaken to search for alternatives to classical HRT. Phytoestrogens are claimed to be capable of positively influencing menopausal symptoms, including hot flushes. We designed a long-term study of 3 months to assess the effects of subcutaneous and orally fed 17beta-estradiol (E2), as well as the actions of resveratrol (RES) on pituitary function in female rats. Our results have demonstrated that RES binds with a 10-fold lower affinity to estrogen receptor (ER)-alpha than to ERbeta. The data from the in vivo study revealed that a dosage of 5 microg and 50 microg RES/kg bodyweight per day given to ovariectomized (OVX) rats achieved serum levels of 1.0 and 8.1 microM respectively. Long-term treatment of OVX rats with RES revealed no estrogenic potential on pituitary function in vivo as assessed by LH and prolactin secretion and by regulation of mRNAs for LHalpha, LHbeta, and GnRH receptor. Subcutaneous treatment with E2 in silastic capsules exerted stronger effects on LH and prolactin secretion, as...Continue Reading

Citations

Mar 19, 2013·Cardiovascular Toxicology·Anna Maria PosadinoGianfranco Pintus
Oct 2, 2008·Nature Reviews. Drug Discovery·Siva LavuPhilip D Lambert
Dec 18, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Valeria PasciuGianfranco Pintus
Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Madhan SubramanianP S MohanKumar
Jul 9, 2008·Translational Oncology·Alexander SchlachtermanSurangani F Dharmawardhane
Nov 28, 2013·Molecular and Cellular Endocrinology·Georgios KararigasHubertus Jarry
Nov 23, 2011·Clinical Neurology and Neurosurgery·Chao WangJun-sheng Wang
Feb 7, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anna Maria PosadinoGianfranco Pintus
Oct 16, 2012·Nutrition and Cancer·Linette Castillo-Pichardo, Suranganie F Dharmawardhane
Mar 22, 2020·International Journal of Molecular Sciences·Abdullah ShaitoGianfranco Pintus
Aug 22, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kaja TikkRudolf Kaaks
May 1, 2021·Antioxidants·Beatriz Moreira-PintoIrene Rebelo

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