Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhoea and faecal incontinence

Scandinavian Journal of Gastroenterology
W M SunM Verlinden

Abstract

Loperamide improves anorectal function in patients with chronic diarrhoea. We wished to investigate whether the prodrug loperamide oxide has similar effects. Eleven patients with chronic diarrhoea and faecal incontinence participated in a randomized, placebo-controlled, double-blind, crossover study of the effects of loperamide oxide (4 mg twice daily for 1 week). Loperamide oxide reduced wet stool weight and improved the patients' ratings of symptoms. Mouth-to-caecum transit time was not altered, but whole-gut transit time was prolonged. There were limited effects on anorectal function, but the mean minimum basal pressure mainly contributed by the internal anal sphincter (IAS) was increased, as was the mean volume infused before leakage occurred in the saline continence test. Loperamide oxide is effective in the treatment of diarrhoea with faecal incontinence; normalization of colon transit time and an increase in the tone of the IAS seem to be the main determinants of efficacy.

References

Oct 1, 1989·Scandinavian Journal of Gastroenterology·R EmblemL Mørkrid
Jul 1, 1987·Gastroenterology·S Rattan, P J Culver
Mar 1, 1984·Digestive Diseases and Sciences·P A CannD Barends
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen

Citations

Jan 24, 2002·Diseases of the Colon and Rectum·William E WhiteheadN J Norton
Oct 17, 2007·International Journal of Colorectal Disease·Jose M Remes-TrocheS S C Rao
Feb 5, 2005·Diseases of the Colon and Rectum·Christopher L H ChanP J Lunniss
Jan 10, 2006·Diseases of the Colon and Rectum·Marije DeutekomPatrick M M Bossuyt
Sep 1, 2005·Digestive Diseases and Sciences·Mark FoxMiriam Thumshirn
Sep 22, 2000·Current Gastroenterology Reports·B Coulie, M Camilleri
Jul 27, 2005·Current Gastroenterology Reports·Kirsten Tillisch, Lin Chang
Jul 27, 2001·Current Treatment Options in Gastroenterology·Ronald Fogel
Jul 13, 2005·Current Treatment Options in Gastroenterology·Arnold Wald
Nov 30, 2000·Current Treatment Options in Gastroenterology·B Krevsky
Dec 10, 1999·The American Journal of Medicine·M Camilleri
Aug 3, 2001·Primary Care·M L Borum
Jun 8, 2001·Gastroenterology Clinics of North America·M J CheethamM A Kamm
Aug 8, 2001·The British Journal of Surgery·A J MaloufM A Kamm
Nov 9, 2002·Journal of Gastroenterology and Hepatology·Chih-Yen ChenShou-Dong Lee
Apr 20, 2007·The New England Journal of Medicine·Arnold Wald
May 5, 2001·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·D Zimmaro Bliss
Aug 26, 2010·The American Journal of Nursing·Donna Zimmaro Bliss, Christine Norton
May 3, 2003·The Journal of Clinical Investigation·David PhilippePierre Desreumaux
Feb 1, 2014·Current Urology Reports·C A UngerJ E Jelovsek
Feb 28, 2014·International Urogynecology Journal·Sara B CichowskiYuko M Komesu
Jul 16, 2014·The American Journal of Gastroenterology·Arnold WaldWilliam E Whitehead
Dec 17, 2008·Women's Health·Ashima MakolWilliam E Whitehead
Jan 25, 2007·Expert Opinion on Investigational Drugs·Peter Holzer
Nov 28, 2013·Gastroenterology Clinics of North America·Joshua I S Bleier, Brian R Kann
Aug 25, 2012·Gastroenterology Clinics of North America·Jan Tack
Nov 10, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·V S TheisS Lal
Sep 29, 2009·Seminars in Pediatric Surgery·Cheryl E Gariepy, Hayat Mousa
Jul 15, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A VillotT Thubert
Feb 19, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B GeeraertsJan Tack
Jul 16, 2010·Alimentary Pharmacology & Therapeutics·Adil E BharuchaA R Zinsmeister
Jan 22, 2014·The British Journal of Surgery·Emma J HorrocksCharles H Knowles
Feb 14, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·V VittonH Damon
May 6, 2005·Journal of the American Medical Directors Association·Abbasi J Akhtar, Manmeet Padda
Jul 16, 2003·Gastroenterology Clinics of North America·Heidemarie Hinninghofen, Paul Enck
Mar 9, 2010·Journal of Medical Case Reports·Udeme E EkrikpoAbideen O Oluwasola
Sep 17, 2008·Gastroenterology Clinics of North America·Christine Norton
Mar 4, 1999·Primary Care·D Nagle
Mar 8, 2017·Journal of Clinical Gastroenterology·Alexandra GuillaumeBani Chander Roland
Jul 3, 2015·Therapeutic Advances in Gastroenterology·Alfred D Nelson, M Camilleri
Jul 27, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A WasilewskiJ Fichna
May 23, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·M CamilleriDavid A Katzka
Sep 12, 2012·The American Journal of Gastroenterology·Brijen J ShahSuzanne Rose
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H U De SchepperM Camilleri
Aug 17, 2004·The American Journal of Gastroenterology·S S C Rao, American College of Gastroenterology Practice Parameters Committee
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Camilleri
Jun 15, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Adil E Bharucha
Jan 6, 2007·Journal of Pediatric Gastroenterology and Nutrition·Marloes E J BongersMarc Alexander Benninga
Jan 16, 2007·The British Journal of Surgery·D R ChatoorAnton Emmanuel
Oct 16, 1999·The American Journal of Gastroenterology·M SchmulsonE A Mayer
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Camilleri
Mar 8, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J R SaundersN S Williams
Jun 13, 2013·The Cochrane Database of Systematic Reviews·Muhammad Imran Omar, Cameron Edwin Alexander
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·A K Tuteja, S S C Rao
Dec 21, 2004·Alimentary Pharmacology & Therapeutics·D Lesbros-PantoflickovaA L Blum
Jan 19, 2008·Annals of the Royal College of Surgeons of England·Oliver M Jones
May 24, 2006·World Journal of Gastroenterology : WJG·Marat Khaikin, Steven-D Wexner
Mar 28, 2018·Current Gastroenterology Reports·Arnold Wald
Feb 23, 2019·United European Gastroenterology Journal·Adam D FarmerJan Tack
Dec 31, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Stefan Müller-LissnerBart Morlion
Oct 5, 2001·Hospital Medicine·M J CheethamM A Kamm
Feb 28, 2004·Alimentary Pharmacology & Therapeutics·O Cheung, A Wald
Aug 26, 2020·Current Gastroenterology Reports·Brototo DebAdil E Bharucha
Feb 5, 2021·Journal of the Anus, Rectum and Colon·Kotaro MaedaFecal Incontinence Guideline Preparation Committee
Feb 4, 2021·Journal of Pediatric Gastroenterology and Nutrition·Shaman RajindrajithMarc Alexander Benninga

Related Concepts

Loperamide oxide monohydrate
Anal Canal
Chronic Disease
Diarrhea
Double-Blind Method
Fecal Incontinence
Gastrointestinal Transit Procedure
Imodium
Rectum
Cross-Over Studies

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