PMID: 2498931Jan 1, 1989Paper

Effects of lorazepam on memory, attention and sedation in man: antagonism by Ro 15-1788

Psychopharmacology
G C PrestonS M Stahl

Abstract

In this study we examined the effects of lorazepam (2.0 mg PO) plus either placebo or one of three doses of the benzodiazepine antagonist Ro 15-1788 (0.3 mg, 1.0 mg or 3.0 mg IV) on measures of memory, attention and sedation. We found that lorazepam impaired verbal secondary memory performance, but also produced subjective and objective sedation; it increased reaction time, reduced critical flicker fusion thresholds and caused subjects to make more errors on a sustained attention task and rate themselves as drowsy. Ro 15-1788 dose dependently blocked the deficit in secondary memory produced by lorazepam, but also showed monotonic dose-related antagonism of its effects on indices of sedation (with the exception of the critical flicker fusion deficit, which was unaffected). These results demonstrate that lorazepam-induced cognitive deficits can be blocked by a benzodiazepine receptor antagonist. They also suggest that the memory deficits produced in this pharmacological model of organic amnesia are not readily dissociated from deficits in attention.

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Citations

Sep 1, 1995·Psychopharmacology·N J WesenstenG L Belenky
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·R K McNamara, R W Skelton
Jun 12, 2003·Behavioural Brain Research·Manish Kumar SarafManjeet Singh
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shahin AkhondzadehLadan Kashani
Sep 4, 1999·Journal of Clinical Pharmacy and Therapeutics·S Akhondzadeh
Aug 4, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Zeidy Muñoz-TorresMaría Corsi-Cabrera
Apr 6, 2000·Psychosomatics·V Rao, C Lyketsos
May 11, 2005·Psychosomatics·Ryan C W HallMarcia J Chapman
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Jun 1, 1997·Journal of Clinical Psychopharmacology·J H TulenA J Man in 't Veld
Jun 8, 2006·Experimental and Clinical Psychopharmacology·Ashley AchesonHarriet de Wit
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Mar 27, 2002·The Psychiatric Clinics of North America·Vani Rao, Constantine G Lyketsos
Oct 21, 2004·Brain Research·Nobuhito YukuhiroMasaomi Miyamoto
Sep 10, 2016·Work : a Journal of Prevention, Assessment, and Rehabilitation·Khosro Sadeghniiat-HaghighiAhmad Khajeh-Mehrizi
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Jul 28, 2004·International Review of Psychiatry·Hochang B LeeVani Rao

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