PMID: 11923591Mar 30, 2002Paper

Effects of lorazepam treatment for multiple ethanol withdrawals in mice

Alcoholism, Clinical and Experimental Research
Howard C Becker, Lynn M Veatch

Abstract

Although many alcohol-dependent patients present with a history of prior detoxifications, the efficacy and safety of pharmacotherapy in the context of multiple ethanol withdrawal experiences have not been extensively studied. The purpose of this study was to evaluate the ability of lorazepam treatment for multiple withdrawals to prevent or blunt the development/expression of sensitized central nervous system hyperexcitability during a subsequent untreated withdrawal episode. A mouse model of withdrawal sensitization involving repeated ethanol withdrawals was used. Adult male C3H/He mice were exposed to different patterns of chronic ethanol vapor in inhalation chambers. One group received four cycles of 16 hr of ethanol exposure separated by 8-hr withdrawal periods, another group was tested after a single 16-hr exposure period, and a final group served as ethanol-naïve controls. These groups were further divided into lorazepam dosage (0.25-1.0 mg/kg) conditions. Lorazepam was administered 1 hr into each of the first three withdrawal cycles (or equivalent times); no drug injections were given during the final (fourth) withdrawal cycle. The ability of lorazepam treatment to alter development and expression of sensitized handling-i...Continue Reading

References

Jul 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·J C Ballenger, R M Post
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·R Z Litten, J P Allen
Jan 1, 1990·Journal of Psychiatric Research·D J GreenblattR I Shader
Jan 1, 1991·Annual Review of Medicine·M K Romach, E M Sellers
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·M F Mayo-Smith, D Bernard
Oct 1, 1995·Psychopharmacology·J UlrichsenR Hemmingsen
Apr 1, 1996·Alcoholism, Clinical and Experimental Research·L M Veatch, L P Gonzalez
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·H C Becker
May 1, 1997·Pharmacology, Biochemistry, and Behavior·H C BeckerR L Hale
Mar 27, 1999·The New England Journal of Medicine·G D'OnofrioE S Freedland
May 8, 2000·Alcoholism, Clinical and Experimental Research·L M Veatch, L P Gonzalez
Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·M C MhatreL P Gonzalez
Mar 28, 2001·The American Journal on Addictions·R MalcolmJ C Ballenger

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Citations

Jan 18, 2007·Behavior Genetics·Pamela MettenJohn C Crabbe
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David N Stephens, Theodora Duka
Feb 13, 2010·Addiction Biology·Markus HeiligHoward C Becker
Dec 24, 2005·Epilepsy Currents·Michael A Rogawski
Aug 23, 2006·Genes, Brain, and Behavior·A S Beadles-Bohling, K M Wiren
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Carl L FaingoldLarry P Gonzalez
Apr 17, 2008·British Journal of Pharmacology·D Nutt, A Lingford-Hughes
Nov 27, 2008·Alcoholism, Clinical and Experimental Research·David F WernerGregg E Homanics
Jul 28, 2011·Alcoholism, Clinical and Experimental Research·Michele T Yip-SchneiderC Max Schmidt
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Pamela MettenJohn C Crabbe
Apr 15, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Melissa A RiegleDwayne W Godwin
Jun 19, 2018·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Melissa L MasicampoDwayne W Godwin
Apr 26, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Howard C BeckerLynn M Veatch

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