Effects of lornoxicam on the hemodynamic and catecholamine response to laryngoscopy and tracheal intubation

European Journal of Clinical Pharmacology
Mohamed Daabiss, Mohamed Hashish

Abstract

Laryngoscopy and tracheal intubation are associated with hemodynamic responses that might increase morbidity and mortality in some patients. Lornoxicam is a nonsteroidal anti-inflammatory drug, which, when added to fentanyl, successfully attenuated the pressor response of intubation. The aim of this study was to evaluate the effect of lornoxicam on the hemodynamic response and serum catecholamine levels following laryngoscopy and tracheal intubation. Fifty adult patients scheduled for general anaesthesia with endotracheal intubation were enrolled in this randomized, double-blind placebo-controlled study. They were divided into two equal groups to receive intravenously either lornoxicam 16 mg or placebo 30 min before surgery. Mean arterial pressure and heart rate were recorded before and after induction of anaesthesia, and every minute after intubation for 10 min. Serum catecholamine levels were measured before induction and 1 min after intubation. After induction, there was a significant decrease in blood pressure in both groups. In the first 3 min after tracheal intubation, a significant increase in the hemodynamic parameters and in the serum norepinephrine level was observed in the control group. Lornoxicam 16 mg attenuates t...Continue Reading

References

Jan 1, 1992·Annales Françaises D'anesthèsie Et De Rèanimation·N BruderC Granthil
Jul 1, 1991·Acta Anaesthesiologica Scandinavica·H G HassanA Fouda
Oct 1, 1988·Postgraduate Medical Journal·S I AnkierH P Ferber
Mar 1, 1987·British Journal of Anaesthesia·A J ShribmanK J Achola
Feb 1, 1983·Analytical Biochemistry·J M Holly, H L Makin
Aug 1, 1981·British Journal of Anaesthesia·W J RussellS E Drew
Feb 1, 1996·Journal of Clinical Anesthesia·A L Kovac
Mar 12, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Buritova, J M Besson
Aug 6, 1999·Journal of Clinical Pharmacology·H StaunstrupK Krøner

Citations

May 30, 2013·Expert Opinion on Pharmacotherapy·Christian Hillstrom, Jan G Jakobsson

Related Concepts

Lornoxicam
Teens
Analgesics, Anti-Inflammatory
Diastolic Blood Pressure
Double-Blind Method
Epinephrine Acetate
Pulse Rate
Hemodynamics
Intubation, Intratracheal
Laryngoscopic Surgical Procedures

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