PMID: 8997184Dec 1, 1996Paper

Effects of lost surface area on red blood cells and red blood cell survival in mice

The American Journal of Physiology
R E Waugh, I H Sarelius

Abstract

The effects of removing area from mouse red blood cells on the fate of the cells after reinfusion were investigated. When cells were made nearly spherical (by reducing cell area by approximately 35%) and then reinfused into the animal, most were cleared from the circulation within 1-2 h, although approximately 20% of the cells survived for 4 h or longer. When only 20% of the area was removed (leaving a 15% excess), more than 90% of the cells continued to circulate for 4 h. After reinfusion, the mean surface area of the surviving cells remained constant (73-75 microns2), but the mean volume decreased, from 56.6 +/- 2.1 to 19.1 +/- 1.5 microns3 (+/- SD of 5 replicates) over 4 h. These changes did not occur in cells suspended in plasma but not reinfused into the animal. Thus a loss of surface area results in a decrease in cell volume, as if to maintain a requisite degree of deformability. The results support the hypothesis that the increase in cell density associated with increasing cell age may be a consequence of surface area loss.

References

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Citations

Feb 2, 1999·The Journal of Clinical Investigation·Z T ShiJ G Conboy
Jul 8, 2011·Cell Biochemistry and Biophysics·Guilherme Santos Duarte LemosNilson Penha-Silva
May 30, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Esam T Ahmed MohamedWolfgang Grill
May 29, 2013·Advanced Materials·Weiwei GaoLiangfang Zhang
Sep 26, 2000·American Journal of Physiology. Cell Physiology·R C MurdockR E Waugh
Feb 13, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anamarija MeglicRajko B Kenda
Mar 11, 2008·Blood Cells, Molecules & Diseases·Seth L AlperCarlo Brugnara
Jan 14, 2003·Biophysical Journal·Sean C GiffordMark W Bitensky

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