Abstract
To evaluate the effect of lovastatin alone or combined with radiation on U87MG and FaDu cells in vitro and U87MG tumors in vivo. Cell number, p21(WAF1) expression, apoptosis, reproductive cell death, and cell-cycle distribution were investigated after incubation of U87MG and FaDu cells in vitro. The effect of lovastatin (50 mg/kg/day) on tumor growth and on tumor growth delay after single-dose irradiation with 20 Gy was investigated using U87MG tumors in nude mice. Lovastatin dose dependently decreased cell number and proliferation of U87MG and FaDu cells. The proportion of cells in G0/G1 phase, apoptosis and p21 protein expression increased after lovastatin alone or combined with 4-Gy irradiation in both cell lines. Effects of lovastatin on cell cycle and cell number were more pronounced in U87MG compared to FaDu. No radiosensitization of clonogenic cells by lovastatin could be demonstrated in both cells lines, but the colony-forming ability after lovastatin alone was decreased in FaDu cells. In vivo, lovastatin decreased tumor volume over time but did not increase growth delay after irradiation of U87MG tumors with 20 Gy. The data support effects of lovastatin on proliferation, apoptosis and colony-forming ability in vitro an...Continue Reading
Citations
Dec 2, 2010·Cancer Chemotherapy and Pharmacology·Jorge Humberto Tapia-PérezThomas Schneider
Apr 30, 2010·Neurosurgical Review·Jorge Humberto Tapia-PérezThomas Schneider
May 15, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Cornelia CzembirekDietmar Thurnher
Feb 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Angelika Zabel-du BoisPeter E Huber
Mar 27, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christina Eder-CzembirekDietmar Thurnher
Jan 15, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank Michael KlenkeAxel Sckell
Jan 27, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Katrin MandaGunther Klautke
Sep 17, 2015·British Journal of Clinical Pharmacology·Dayle Rundle-ThieleJennifer H Martin
Aug 30, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maja MisirkicVladimir Trajkovic
Jun 16, 2009·Medicinal Research Reviews·Marek Jakobisiak, Jakub Golab
Mar 6, 2015·PloS One·Li-Han ChinYu-Chih Liang
Jun 23, 2015·PloS One·Ludmila Madeira Cardoso PavanEliete Neves Silva Guerra
Apr 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruchika GuttStanley L Liauw
Oct 25, 2014·Toxicologic Pathology·André Lisboa RennóAndré Almeida Schenka
Apr 8, 2020·Journal of Translational Medicine·Shabnam TahamtanAmirhossein Sahebkar
Aug 31, 2010·Journal of Neuro-oncology·Sonja GehringChristian Mawrin
Jun 2, 2017·Experimental and Therapeutic Medicine·Hiroshi DoiShozo Hirota
May 21, 2009·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Alastair J Munro
Aug 1, 2020·Cancers·Rachmad Anres DongoranChin-Hung Liu
Jul 3, 2021·Cells·Elena BianchettiKevin A Roth
Aug 19, 2020··Yan-Ying YangQiang Xue