Effects of Lovastatin on MDA-MB-231 Breast Cancer Cells: An Antibody Microarray Analysis

Journal of Cancer
Tao YangXiyun Deng

Abstract

Despite the tremendous improvement in cancer therapeutics, treatment of late-stage breast cancer remains a challenge for both basic scientists and clinicians. Lovastatin, a natural product derived from Aspergillus terreus or Monascus ruber, has been widely used as cholesterol-lowing drug in the clinic. It also has anti-cancer properties through poorly defined molecular mechanisms. In the present study, we employed a novel antibody microarray technology to investigate the molecular mechanisms through which lovastatin inhibits breast cancer. We found that lovastatin up-regulated 17 proteins and down-regulated 20 proteins in MDA-MB-231 breast cancer cells. These included proteins that modulate apoptosis, cell proliferation, differentiation, signal transduction, epithelial-to-mesenchymal transition and tumor metastasis. Modulation of these pathways may mediate, in part, the inhibitory activity of lovastatin on breast cancer.

Citations

Jul 28, 2016·Applied Microbiology and Biotechnology·Ying YinYuanxing Zhang
Mar 7, 2018·Clinical Proteomics·Ziqing ChenSheng-Ce Tao
Apr 27, 2019·Pharmacological Reports : PR·Luz X Vásquez-BochmMarco A Velasco-Velázquez
Nov 22, 2018·Breast Cancer Research : BCR·Colin H BeckwittAlan Wells
Mar 16, 2017·Journal of Cellular and Molecular Medicine·Hui YaoXiyun Deng
Jun 7, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bárbara CostaNuno Vale
Aug 27, 2021·Cellular Signalling·Liguo XieYunlin Wei

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
PCR

Software Mentioned

Database for Annotation , Visualization and Integrated Discove...
CellQuest Pro

Related Concepts

Related Feeds

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis