PMID: 15220204Jun 29, 2004Paper

Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes

Diabetes
Darleen A SandovalStephen N Davis

Abstract

Antecedent moderate-intensity exercise has been shown to blunt autonomic, neuroendocrine, and metabolic counterregulatory responses to subsequent hypoglycemia in nondiabetic individuals. The aims of the current study were to determine 1) whether this occurs in type 1 diabetic patients and 2) whether the degree of blunting is dependent on exercise intensity. Twenty-seven type 1 diabetic patients (13 women and 14 men) were studied during a single-step, 2-h hyperinsulinemic (9 pmol x kg(-1) x min(-1))-hypoglycemic (approximately 2.8 mmol/l) clamp 1 day after two 90-min exercise bouts at 30% (n = 11) or at 50% (n = 11) Vo(2max) or after no prior stress (control subjects, n = 25). After prior exercise at both 30 and 50% Vo(2max), epinephrine (1,959 +/- 553 and 1,528 +/- 424 vs. 3,420 +/- 424 pmol/l, respectively; P < 0.05) and pancreatic polypeptide (97 +/- 32 and 98 +/- 8 vs. 223 +/- 32 pmol/l, respectively; P < 0.05) responses to subsequent hypoglycemia were significantly lower compared with those of control subjects. Endogenous glucose production was significantly lower, while glucose utilization and, consequently, the exogenous glucose infusion rate needed to maintain hypoglycemia were significantly greater after both exercise i...Continue Reading

References

Sep 1, 1979·The American Journal of Physiology·R A DeFronzoR Andres
Aug 1, 1991·International Journal of Sports Medicine·J NagasawaT Ishiko
Jul 1, 1970·Analytical Biochemistry·R J Ho
Aug 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K N Frayn
Aug 1, 1983·The American Journal of Physiology·W HagopianJ B Jaspan
Sep 1, 1981·Analytical Biochemistry·R C CausonR Rodnight
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 1, 1993·Diabetes Care·D J CoxW L Clarke
Aug 1, 1996·The Journal of Clinical Investigation·S N DavisR Mosqueda-Garcia
Apr 1, 1997·The American Journal of Physiology·J JensenO Brørs
Sep 2, 1998·The American Journal of Physiology·R Aslesen, J Jensen
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·S N DavisF Costa
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·P GalassettiS N Davis
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·K ShumM Vranic
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·P GalassettiS N Davis
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S B EvansD P Figlewicz
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·P E Cryer
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Veronica P McGregorPhilip E Cryer
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Yoshiharu KoyamaDavid H Wasserman
Jun 28, 2003·Diabetes·Darleen A SandovalStephen N Davis
Apr 1, 1957·The American Journal of Physiology·J S WALLN ALTSZULER

❮ Previous
Next ❯

Citations

Apr 18, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C HerderS Martin
Jan 5, 2011·Diabetes, Obesity & Metabolism·I W GallenA Lumb
Feb 16, 2006·The Journal of School Health·Maryann MasonCatherine Ashlaw
Apr 26, 2006·The Journal of School Health·Ximena Urrutia-Rojas, John Menchaca
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Vanessa Jones BriscoeStephen Neil Davis
Dec 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Sofiya MilmanIlan Gabriely
Jul 2, 2009·Medicine and Science in Sports and Exercise·Katarina T BorerCharles F Burant
Nov 30, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ramin AlemzadehJessica Kichler
Apr 3, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Cosimo GianniniFrancesco Chiarelli
Nov 1, 2012·Nutrients·Stefanie J HerringtonKelly L Pritchett
Jul 9, 2014·Molecular and Cellular Endocrinology·Malihe AvesehSaeed Esmaeili-Mahani
Mar 21, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Alistair N Lumb, Ian W Gallen
Feb 23, 2011·Expert Review of Endocrinology & Metabolism·Lisa M YounkStephen N Davis
Aug 7, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Pedro Mezquita-RayaUNKNOWN Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition (SEEN)
Aug 21, 2010·Endocrinology and Metabolism Clinics of North America·Philip E Cryer
May 28, 2008·Journal of the American Dietetic Association·Charlotte Hayes, Andrea Kriska
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Sep 17, 2009·Pediatric Diabetes·William ClarkeGeorgeanna J Klingensmith
Sep 17, 2009·Pediatric Diabetes·Kenneth RobertsonMichael C Riddell
Oct 3, 2008·Pediatric Diabetes·Jaime S Rosa, Pietro R Galassetti
Apr 18, 2008·Pediatric Diabetes·William ClarkeGeorgeanna J Klingensmith
Jul 31, 2007·Pediatric Diabetes·UNKNOWN Diabetes Research in Children Network (DirecNet) Study Group
Jan 24, 2008·Pediatric Diabetes·Kenneth RobertsonRagnar Hanas
Mar 20, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·J W SacreT H Marwick
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A J Graveling, B M Frier
Nov 27, 2008·Diabetes·Philip E Cryer
Jun 23, 2016·Diabetes Research and Clinical Practice·Jan-Willem van DijkLuc J C van Loon
Feb 18, 2011·The Diabetes Educator·Mercy DevadossNancie Herbold
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ulrik Pedersen-BjergaardBirger Thorsteinsson
Aug 7, 2012·Journal of Attention Disorders·Sharon B WigalPietro Galassetti
Jul 10, 2012·Journal of Diabetes Science and Technology·Philip J JohnsonNat T Messer
Jun 7, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·N ParamalingamT W Jones
Jan 9, 2015·Journal of Diabetes Science and Technology·Sheri R ColbergDavid Kerr
Feb 24, 2006·Pediatric Diabetes·M C Riddell, K E Iscoe
Jun 16, 2011·The Physician and Sportsmedicine·Lisa ChuMichael C Riddell
Jan 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·Pietro GalassettiStephen N Davis

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